Nippon Chemical Industrial Co., Ltd.

Other

Hiroshi Kawakabe

Nobuo Matsumoto

Yasuko Manabe

Masashi Sugiya

Huy Sam

Yoshifusa Hara

Hiromu Tsutiya

Atsushi Wakui

Tomohisa Kamata

An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals.

Process for producing 3-chloromethyl-3-cephem derivatives

A chlorinated azetidinone derivative expressed by Formula (1) and an alcoholate are allowed to react in a solvent containing at least one of alcohols and an ether at a pH of 8 or less. Thus a 3-chloromethyl-3-cephem derivative expressed by Formula (2) is prepared.  In the formulas, Rrepresents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic residue, and Rand Reach represent a substituted or unsubstituted aromatic hydrocarbon group.

Process for preparing crystalline 3-chloromethyl-3-cephem derivatives

Catalyst for curing epoxy resins, method for making the same, epoxy resin composition, and powder coating composition

Non-aqueous electrolyte secondary battery

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Tokyo, Japan

Hiroshi Kawakabe