Hitachi Chemical Company, Ltd.

Hitachi Chemical Research Center, Inc.

Hiroshi Izutsu

Kazuhiko Obara

Akira Matsumoto

Masato Mitsuhashi

Mitsuo Yamaki

Kiyotaka Kawagoe

Katsuya Endo

Shuji Ohta

Akifumi Iguchi

Toshihide Morikawa

A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of tumor necrosis factor superfamily ('TNFSF')-2, TNFSF-8, or TNFSF-15 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed.

Enhanced FC receptor-mediated tumor necrosis factor superfamily MRNA expression in peripheral blood leukocytes in patients with rheumatoid arthritis

antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; a method for production of an anti- antibody, wherein the antigenic polypeptide is used as an antigen; a method for detection and/or measurement of an anti- antibody, which comprise the antigenic polypeptide as an antigen; agents for diagnosis of infections, which comprise the antigenic polypeptide as an active ingredient; fused proteins of an antigenic polypeptide of with dihydrofolate reudctase; a method for production of an anti- antibody, wherein the fused protein is used as an antigen; reagents for detection and/or measurement of an anti- antibody, which comprise the fused protein as an antigen; agents for diagnosis of infections, which comprise the fused protein as an active ingredient.

Chlamydia pneumoniae antigenic polypeptide

antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1, DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; a method for detection and/or measurement of an anti- antibody, wherein the antigenic polypeptide is used as an antigen; reagents for detection and/or measurement of an anti- antibody, which comprise the antigenic polypeptide as an antigen; agents for diagnosis of infections, which comprise the antigenic polypeptide as an active ingredient; fused proteins of an antigenic polypeptide of with dihydrotolate reductase, in which polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1 is bound to the polypeptide of SEQ ID NO: 14 either directly or via an intervening amino acid or amino acid sequence; DNAs encoding the fused proteins, or DNAs complementary thereto.

Method of detecting anti-Chlamydia pneumoniae antibody using Chlamydia pneumoniae-specific antigens

antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the antigenic polypeptides, or DNAs complementary thereto; DNAs encoding the probes and primers for detection and/or measurement of gene. The present invention further provides a method for detection and/or measurement of gene, wherein the probe or primer is used; reagents for detection and/or measurement of gene, which comprise the probe or primer; and agents for diagnosis of infections, which comprise the probe or primer as an active ingredient.

Method of detecting chlamydia pneumoniae gene using polynucleotides

DNA encoding Chlamydia pneumoniae antigenic polypeptide

Chlamydia pneumoniae antigens, method for production of the antigens,

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Ibaraki, Japan

Hiroshi Izutsu