Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Hiroshi Ishida

Hitoshi Arai

Tsutomu Matsumura

Yoshinori Yamashita

Yuichi Takahashi

Etsuo Ohshima

Ichiro Miki

Yukimasa Shiotsu

Kimihisa Ueno

Tomoki Naoe

Satoshi Nakanishi

Hitoshi Kiyoi

Ryuichiro Nakai

Seiji Aratake

Koji Suzuki

Koji Yanagawa

Motoki Miyama

Hiroshi Umehara

Keiichi Motosawa

Katsuya Kobayashi

Koji Hagihara

Nana Oiwa

Yosuke Yamaura

Ari Kawabe

Takashi Sato

Shinya Fujii

Yusuke Miura

Syoichi Isami

Miho Iwase

Ryoko Okada

A Wnt signaling inhibitor which comprises, as an active ingredient, a fused-ring heterocyclic compound represented by the following formula (IA) or a pharmaceutically acceptable salt thereof, and the like are provided: (wherein, nrepresents 0 or 1; nand nmay be the same or different, and each represents 1 or 2; Rrepresents optionally substituted aryl or the like; Rrepresents a hydrogen atom or the like; Rrepresents an optionally substituted aromatic heterocyclic group or the like; X, X, Xand Xeach represent CH or the like; Yrepresents CHor the like; Yrepresents N or the like; and Lrepresents CHor the like).

Wnt signaling inhibitor

The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein &#x2014;X&#x2014;Y&#x2014;Z&#x2014; represents &#x2014;O&#x2014;CR&#x2550;N&#x2014; (wherein Rrepresents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

Pyrimidine derivative compound

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); Rrepresents the above Formula (II), Formula (IV) or the like; A represents a single bond, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;OC(&#x2550;O)&#x2014; or the like; and Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like] Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.

Bicyclic pyrimidine derivatives

Growing community of inventors

Sunto-gun, Japan

Hiroshi Ishida