Schering Corporation

New Japan Chemical Co., Ltd.

Hiroshi Ishida

Albert Zlotnik

Maureen C Howard

Di-Hwei Hsu

Anne O'Garra

Hergen Spits

Rene De Waal Malefyt

Yasuyuki Kawahara

Shinya Tsujimoto

Rene De Malefyt

An object of this invention is to provide a lubricating base oil that has a small rate of change in viscosity (a high viscosity index) over a wide temperature range, low viscosity at low temperatures, and good low-temperature fluidity and evaporation resistance, and that allows reduced decomposition thereof. To achieve the object, methylpentanediol diesters obtained by using specific aliphatic monocarboxylic acids are used as a lubricating base oil.

Lubricant base oil for fluid bearing

A method is provided for toting a B cell mediated autoimmune disorder comprising administering an effective amount of an interleukin-10 antagonist.

Use of an interleukin-10 antagonist to treat a B cell mediated

A method is provided for reducing an inflammatory response in a mammal comprising administering to a mammal at risk of developing or afflicted with an inflammatory response characterized by substantially elevated levels of IL-1.alpha., IL-1.beta., IL-6, IL-8 and TNF.alpha., an amount of IL-10 effective to substantially lower the levels of such cytokines.

Use of interleukin-10 analogs for antagonists to treat endotoxin- or

A method is provided for treating septic shock or toxic shock that comprises administering an effective amount of interleukin-10.

Use of interleukin-10 (IL-10) to treat endotoxin- or

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Kyoto, Japan

Hiroshi Ishida