Teijin Limited

Hiroshi Ikura

Yoshiki Suzuki

Tsuneji Nagai

Gentaro Yamashita

Yoshiharu Machida

Toshihide Noguchi

Shiro Kinoshita, Deceased

Katsunori Izumizawa

A powdery pharmaceutical composition for application to the mucosa of the oral or nasal cavity including: (a) a base selected from the group consisting of lower alkyl ethers of cellulose; (b) a pharmaceutically effective amount of a drug selected from the group consisting of steroid or glycyrrhizic acid type anti-inflammatory agents; and (c) a stabilizer for the drug composed of at least one low irritant solid organic acid selected from the group consisting of saturated higher aliphatic monocarboxylic acids having 12 or more carbon atoms, aliphatic polycarboxylic acid, hydroxy aliphatic polycarboxylic acids, aromatic carboxylic acids, unsaturated lower aliphatic monocarboxylic acids having six or less carbon atoms, and cellulose derivatives having carboxyl group. This powdery pharmaceutical composition has extremely excellent stability in the steroid or glycyrrhizic acid type anti-inflammatory agent contained therein, low irritation of the mucosa of the oral or nasal cavity, and sustained release of the drug over an extended period of time.

Powdery pharmaceutical composition suitable for application to mucosa of

This invention is concerned with an oral sustained release pharmaceutical preparation which is prepared as a pharmaceutical preparation comprising lower alkyl ether of cellulose, polyacrylic acid or its pharmaceutically acceptable salt, and active drugs, or a pharmaceutical preparation comprising lower alkyl ether of cellulose, polyacrylic acid or its pharmaceutically acceptable salt, and active drugs together with a foaming agent, so that it may release the active drugs by such slow degrees in the stomach or the intestinal tract as to make it possible to provide an adequate supply of active drugs in enough concentration to display their therapeutic value for many hours.

Oral sustained release pharmaceutical preparation

The present invention relates to a method for treating an injured part on the oral mucosa, which comprises covering the injured part with a covering material consisting essentially of a cellulose lower alkyl ether and a polyacrylic acid or its pharmaceutically acceptable salt, and to said covering material. According to the present invention, without using a medicament, the injured part on an oral mucosa can be cured rather rapidly simply by covering the injured part.

Method of treating an injured part on the oral mucosa and the covering

A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical preparation comprising a water-soluble polymeric substance having a Young's modulus of 10 to 250 Kg/mm.sup.2 as determined at a temperature of 25.degree. C. and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20.degree. C. and a medicinal agent for remedy of periodontal diseases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic solvent by drying to obtain a pharmaceutical preparation in the form of a film or sheet.

Pharmaceutical preparation for remedy of periodontal disease and process

A powdery pharmaceutical composition and a powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said composition comprising a lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug; and a method for treating or preventing a human nasal disease, which comprises administering a powdery preparation in unit dosage form to the nasal cavity of a human being requiring treatment or prevention of a nasal disease through his nostrils.

Powdery pharmaceutical composition and powdery preparation for

PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980 A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.

Slow-releasing medical preparation to be administered by adhering to a

A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising

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Hino, Japan

Hiroshi Ikura