The Green Cross Corporation

Senju Pharmaceutical Co., Ltd.

Sapporo Breweries Limited

Hiroshi Hosono

Tetsuo Matsui

Yoshiyuki Nakamura

Tomoji Aotsuka

Hiromichi Ishikawa

Toshiyuki Nishio

Toshio Kurihara

Fujio Kobayashi

Takema Hase

Takahiro Kumonaka

Chikako Shimizu

Succinamic acid compound, production method thereof and use thereof

A pyridothiazineacetic acid compound of the formula (I) ##STR1## wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, production thereof, and a pharmaceutical composition, an aldose reductase inhibitor and a preparation for the prevention and treatment of the complications of diabetes, containing the same. The pyridothiazineacetic acid compound and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory action and are superior in safety. Accordingly, they are useful as a preparation for the prevention and treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly, cataract and neurosis. In addition, the production method of the present invention enables efficient production of said pyridothiazineacetic acid compound.

Pyridothiazineacetic acid compound, production thereof and use thereof

Quinoline-3-acetic acid derivative, process for production thereof and

Benzothiazole compound, production thereof and use thereof

1,4-Benzothiazine-2-acetic acid derivatives having an excellent aldose reductase inhibitory activity which are useful for the prevention and treatment of diabetic complications, such as diabetic cataract, retinopathy, nephropathy and neuropathy.

1,4-benzothiazine-2-acetic acid derivatives

Growing community of inventors

Ibaraki, Japan

Hiroshi Hosono