Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Hiroshi Hatanaka

Masakuni Okuhara

Hirokazu Tanaka

Toshio Goto

Tohru Kino

Shigehiro Takase

Masanori Okamoto

Eisaku Tsujii

Masami Ezaki

Nobuharu Shigematsu

Seiji Hashimoto

Michio Yamashita

Keiji Honda

Norihiro Hashimoto

Kohji Kawabata

Yasuhisa Tsurumi

Hidenori Ohki

Kazutoshi Sakamoto

Tomoji Higaki

Takashi Yoshiyasu

Masashi Hashimoto

Keiji Matsuda

Kozo Sawada

Itsuo Uchida

Yasuhiro Hori

Takashi Tojo

Michizane Hashimoto

Nobuyuki Shiraishi

Tsutomu Kaizu

Hidetsugu Murai

Kumiko Nitta

Kunio Nakahara

Takashi Fujita

Toru Kino

Yutaka Nishihara

Koji Mukai

Terumi Okudaira

Noriaki Inamura

Yasuhiko Shinguh

Yoshitada Notsu

Ryuichi Kanasaki

A method for separating a lactone-containing high-molecular weight compound comprising subjecting a mixture of a lactone-containing high-molecular weight compound having, as its side-chain, at least one of a lower alkenyl group and a lower alkoxy group and its analogous compound(s) to either one or both steps in any order of a step (A) for adsorbing the mixture to a nonionic adsorption resin and eluting with an aqueous solvent containing silver ions, and a step (B) for adsorbing the mixture to a basic active alumina and eluting with an organic solvent to separate each of the compounds.

Method for separating lactone-containing high-molecular weight compounds

The present invention relates to a method for separating a lactone-containing high-molecular weight compound having an alkyl group as its side chain from a lactone-containing high-molecular weight compound having an alkenyl group as its side chain by using a sulfonic acid group-containing cation exchange resin pretreated with silver ions.

Method for separating analogous organic compounds

Method for inhibiting interleukin-2 production using tricyclo compounds

Cyclic hexapeptides having antibiotic activity

The invention relates to new polypeptide compounds represented by the following formula &lsqb;I&rsqb;:

Echinocandine derivatives with antimicrobial activity

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula:

Method for inhibiting lymphokine production

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.

Method of immunosuppression

Substance WF16616, process for production thereof, and use thereof

Process for production of tricyclo compounds with streptomyces

Strain of Streptomyces for the production of tricyclo compounds

Tricyclo compounds, a process for their production and a pharmaceutical

FR901451 substance, process for preparation thereof and use thereof

A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.

WS7622A mono- or di-sulfate, process for preparation thereof and use

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Ibaraki, Japan

Hiroshi Hatanaka