City of Sapporo

Hitachi Chemical Company, Ltd.

Showa Denko Materials Co., Ltd.

Hitachi Chemical Research Center, Inc.

Showa Denko Materials (america), Inc.

Hiroshi Harada

Masato Mitsuhashi

Taku Murakami

Cindy M Yamamoto

The present disclosure relates to methods of collecting exosomes and microvesicles (EMV) from urine, isolating corresponding mRNA, and analyzing expression patterns in order to diagnose and treat various urothelial cancers. In particular, various expression patterns are analyzed through a unique diagnostic formula.

Molecular methods for assessing urothelial disease

Embodiments of the invention relate generally to methods of characterizing kidney function. In particular, several embodiments quantify kidney-associated marker RNA isolated from vesicles contained in patient urine samples. In some embodiments, the quantified RNA from urine vesicles is compared to a normal population and in some embodiments is compared to the patient to evaluate kidney function over time.

Methods for characterizing kidney function

Growing community of inventors

Sapporo, Japan

Hiroshi Harada