Ono Pharmaceutical Co., Ltd.

Hiroshi Hagiya

Masaya Kokubo

Masakuni Kurono

Kenichi Kouda

Masashi Minami

Ryosuke Hanada

Shinji Nakade

Hiromu Habashita

Kensuke Kusumi

Haruto Kurata

Takaki Komiya

Takeji Ono

Hiroshi Saga

Hirotaka Mizuno

Kazuhiro Ohtsuki

Hisao Tajima

A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

STING agonistic compound

A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1):

Sting agonistic compound

A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like: 

Compound capable of binding S1P receptor and pharmaceutical use thereof

A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and Ris a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and Ris a substituent, and wherein m is 2 or more, Rs are the same or different.

A plasmid DNA comprising a novel reporter gene DNA; a transformant transformed with the above plasmid DNA and a DNA encoding a known effector protein; a therapeutic agent for a cancer or an autoimmune disease, comprising both of the above DNAs as active ingredients; and a method for detecting a ligand of an intracellular receptor, comprising using the above transformant.

Plasmid DNA containing reporter gene DNA and use of the same

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Osaka, Japan

Hiroshi Hagiya