Banyu Pharmaceutical Co. Ltd

Toshiba Medical Systems Corporation

Nagoya University

Hiroshi Fukatsu

Susumu Nakagawa

Satoshi Murase

Koji Yamada

Ryosuke Ushijima

Kenichi Niwa

Shinji Kato

Fumio Nakano

Norikazu Ohtake

Akira Iwasa

Yoshiaki Kato

Muneyasu Kazuno

Osamu Okamoto

Ryuji Mitomo

Yoshiaki Katoh

Katsumi Yamamoto

Hiroyuki Yamasaki

Maki Minakuchi

Kunio Suzuki

Tetsuji Miyano

Koichi Terai

Kota Ishikawa

According to one embodiment, a medical report writing support system comprises an analyzing unit which analyzes a difference regarding at least one of a change in key images between a first report and a second report regarding a predetermined patient and a change in hyperlinks, and acquires an analyzed result, and a difference information generation unit which generates difference information based on the analyzed result.

Medical report writing support system, medical report writing unit, and medical image observation unit

There are provided an input unit which inputs an object with scan information attached thereto into an image of a subject acquired on the basis of the scan information, and an insertion unit which inserts report information to the object when preparation of an image interpretation report of a study based on the image is completed.

Apparatus and method for storing medical information

The present invention comprises: a data storage unit for storing series image data obtained by medical image acquisition equipment and object data containing image acquisition conditions for the series image data and the specific information for specifying other series image data related to the series image data; an information management unit for generating a thumbnail image that represents combination information of the presently obtained series image data and the past related series image data by referring to the object data; and a display unit for displaying the thumbnail image.

Diagnostic imaging support equipment

In issuing an order, a medical image diagnostic system acquires order issuance support information on the basis of a reference report or a reference image, which an order issuer uses as a basis of order creation. The medical image diagnostic system classifies the order issuance support information on the basis of a table and presents the order issuance support information using a predetermined order issuance support screen. For example, the order issuer selects desired conditions from the order issuance support screen presented to perform order issuance based on the reference report or the like.

Medical image diagnostic system for creating order information

A medical report creating apparatus in which a link corresponding range is specified for any of strings arranged in an observation column in a medical report display screen. Then, a drag operation is input which specifies any of contents being displayed on a monitor. When a dragged display icon is dropped onto a link corresponding range displayed portion of a medical report creation screen to specify the string, address information on the content is acquired. The address information on the referenced content is then pasted to the string. At the same time, the string in the link corresponding range has its color changed and is underlined for identification. After the report has been completed, a file is saved and the series of operations are finished. Then, the file is transferred to, for example, an image interpretation report requester.

Medical report creating apparatus, medical report referencing apparatus, medical report creating method, and medical report creation program recording medium

Carbapenem derivatives

A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, an amino group, an N-lower alkylamino group, an N,N-di-lower alkylamino group, a lower alkanoylamino group, an aroylamino group, a (lower alkylsulfonyl)amino group, a sulfamoylamino group, a cyano group, a nitro group, a group of --COOR.sup.4 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group) or a group of --CON(R.sup.5)R.sup.6 (wherein each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidyl group, a piperazinyl group, a 4-lower alkyl piperazinyl group and a morpholino group), A is a linear or branched lower alkylene group, X is a group of --N(R.sup.7)R.sup.8 (wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom or a lower alkyl group) or a group of --N.sup.+ (R.sup.9)(R.sup.10)R.sup.11 (wherein each of R.sup.9, R.sup.10 and R.sup.11 which may be the same or different, is a lower alkyl group), provided that when A is a linear lower alkylene group, R.sup.3 is other than a hydrogen atom; or a pharmaceutically acceptable salt or ester thereof.

Aminoalkylpyrrolidinylthiocarbapenem derivatives

A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a negative charge, X is a group of --N(R.sup.3)R.sup.4 (wherein R.sup.3 is a lower alkyl group, and R.sup.4 is a hydrogen atom or a lower alkyl group) or a group of --N.sup.+ (R.sup.5)(R.sup.6)R.sup.7 (wherein each of R.sup.5, R.sup.6 and R.sup.7 which may be the same or different, is a lower alkyl group), and n is an integer of from 2 to 4; or a pharmaceutically acceptable salt or ester thereof.

Alkylaminoalkylpyrrolidinylthiocarbapenem derivatives

Carbapenem compounds of formula I and their pharmaceutically acceptable salts and esters are provided: ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, p, q and r are as defined herein, which are useful as antibacterial agents.

2-(substituted pyrrolidinylthio) carbapenem derivatives

A compound of the formula: ##STR1## wherein R is a hydrogen atom or a methyl group, R.sup.1 is a hydrogen atom or a negative charge, each of R.sup.2 and R.sup.3 which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, --COOR.sup.4, --CON(R.sup.5)R.sup.6, --N(R.sup.5)R.sup.6, --CH.sub.2 COOR.sup.4, --CH.sub.2 N(R.sup.5)R.sup.6 or --CH.sub.2 CON(R.sup.5)R.sup.6 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group, each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group and a piperidyl group), A is .dbd.NR.sup.7, .dbd.N.sup.+ (R.sup.7)R.sup.8, wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, --COOR.sup.4, --CON(R.sup.5)R.sup.6, --N(R.sup.5)R.sup.6, --CH.sub.2 COOR.sup.4, --CH.sub.2 N(R.sup.5)R.sup.6 or --CH.sub.2 CON(R.sup.5)R.sup.6 (wherein R.sup.4, R.sup.5 and R.sup.6 are as defined above), p is an integer of from 0 to 3, and q is an integer of from 1 to 3; or a pharmaceutically acceptable salt or ester thereof.

2-(substituted pyrrolidinylthio)carbapenem derivatives

A compound of the formula: ##STR1## wherein R is a hydrogen atom or a methyl group, R.sup.1 is a hydrogen atom or a negative charge, R.sup.2 is a lower alkyl group, a lower alkyl group substituted with a hydroxyl group or --COOR.sup.3 (wherein R.sup.3 is a hydrogen atom or a lower alkyl group), A is .dbd.NH, .dbd.NR.sup.4 or .dbd.N(R.sup.4)R.sup.5 (wherein each of R.sup.4 and R.sup.5 which may be the same or different, is a lower alkyl group or a lower alkyl group substituted with a hydroxyl group), p is an integer of from 0 to 3, and each of q and r which may be the same or different, is an integer of from 0 to 5, provided that q and r are not simultaneously 0 and q +r.ltoreq.6; or a pharmaceutically acceptable salt or ester thereof.

A process for producing a 2-(unsubstituted or carbon-substituted)-1-carbapen-2-em-3-carboxylic acid derivative, which comprises reacting a 2-trifluoromethanesulfonyloxy-1-carbapen-2-em-3-carboxylic acid derivative or the 1-carbapen-2-em-3-carboxylic acid derivative derived from a 2-oxo-1-carbapenam-3-carboxylic acid derivative and trifluoromethanesulfonic anhydride, and a stannane derivative in an inert solvent in the presence of a palladium compound and a salt.

Process for producing 2-carbon-substituted carbapenem derivatives

A compound represented by the general formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or taken together with the adjacent nitrogen atom, jointly represent a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group, a 4-lower alkylpiperazinyl group, a morpholino group and a thiomorpholino group; and A is a single bond, a lower alkylene group, a lower alkenylene group or a lower alkynylene group; or a pharmaceutically acceptable salt or ester thereof. The compound of the general formula (I) and their salts or esters exhibit excellent antibacterial activity.

Piperidylthiocarbapenem derivatives

A compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group; R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.4 represents a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a di-lower alkylcarbamoyl group, or a carbonyl group substituted with a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a morpholino group, a thio-morpholino group, a piperazinyl group, and a 4-lower alkyl-1-piperazinyl group, or a pharmaceutically acceptable salt or ester thereof. The compound of formula (I) and their salts or esters exhibit excellent antibacterial activity.

Cyclic amidinylthiocarbapenem derivatives

A cephalosporin derivative having the formula: ##STR1## wherein R.sup.1 is a substituted amino group, X is an alkylene group, R.sup.2 is an aryl or heterocyclic group which may be substituted and R.sup.3 is a hydrogen atom, a negative charge or a residue of an ester which can form a pharmaceutically acceptable ester hydrolyzable in a living body; or a pharmaceutically acceptable salt thereof.

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Nagoya, Japan

Hiroshi Fukatsu