Shionogi Company Limited

Institute of Medicinal Molecular Design, Inc.

Kemphys Ltd.

Hiroshi Fukasawa

Koichi Shudo

Akiko Itai

Susumu Muto

Hiroyuki Kagechika

Miwako Ishido

Tetsuro Matsuishi

Naoko Katsumura

Ryuko Tokuyama

Terukazu Kato

Takeshi Yanase

Takafumi Ohara

Method for therapeutic treatment of inflammatory bowel disease, including Crohn's disease, comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a retinoid as an active ingredient to treat the inflammatory bowel disease, the retinoid being selected from the group consisting of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid, 4-[(3,5-bis-trimethylsilylphenyl)carboxamido]benzoic acid, 4-[2,3-(2,5-dimethyl-2,5-hexano)dibenzo[b,f][1,4]thiazepin-11-yl]benzoic acid, and 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid.

Method for treatment of inflammatory bowel disease

A compound of the formula (I): or a pharmaceutically acceptable salt thereof.

Derivative having PPAR agonistic activity

Method for suppressing adhesion of the intestines or therapeutic treatment of adhesion of the intestines comprising administering to a patient in need thereof a therapeutically effective amount of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid. There is also provided a medicament for suppressing adhesion of the intestines and/or therapeutic treatment of bowel diseases such as inflammatory bowel diseases, including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.

Method for treatment of adhesion of the intestines

Disclosed is a compound which is useful as an 11&#x3b2;-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: 

Oxazolidinone derivative having inhibitory activity on 11&#x3b2;-hydroxysteroid dehydrogenase type 1

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Tokyo, Japan

Hiroshi Fukasawa