Other

Ube Industries, Inc.

Sankyo Company, Limited

Kaneka Corporation

Hiroshi Fujiwara

Shinji Takamura

Tomio Kimura

Nobuhiko Shibakawa

Keiji Matsunobu

Takaaki Toyooka

Masahiko Hagihara

Akira Yorifuji

Motoaki Itadani

Nobuki Tanaka

Shigeharu Ochi

Eiji Okanari

Koji Sugano

Yoshiaki Kuroki

Jun-ichiro Kita

Jun'ichiro Kita

Toshio Onishi

Kayoko Yamano

Sho Inui

Masayuki Tanaka

Yasushi Takahashi

Takahiro Hayashi

Keiichi Ito

Ryuzo Yoshioka

Osamu Kobayashi

Akihide Koda

Tetsushi Katsube

Keiichi Tabata

Haruo Iwabuchi

Jun Fukuzawa

Fuminobu Hirose

Yasuhiko Ozaki

Yasunori Tokunaga

Ryo Iwamura

Hitoshi Ueno

Shin-ichi Yamada

Manabu Shigetomi

Yoshio Kaku

Yoshimi Fujihara, Deceased

Etsuro Itoh

Mikio Kodaka

Yasuo Nishida

Hiroko Honda

Kumiko Murata

Shigeharu Anpeiji

Takashi Ikuta

Hiroshi Kobayashi

The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R, R, R, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. The pyridylaminoacetic acid compound has EP2 agonistic action and is therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases such as asthma or chronic obstructive pulmonary disease.

Pyridylaminoacetic acid compound

Acid addition salt of optically active piperidine compound and process for preparing the same

Pyrrolopyridazine compounds

Optically active pyrrolopyridazine derivatives

This invention provides a rolling mill and a rolling-mill train which are compact. Reducers to be coupled with them can be made compact. The inner surfaces of pipes to be rolled with the rolling mill and the rolling-mill train can be prevented from becoming squarish. The rolling mill comprises a plurality of rolls disposed symmetrically around the pathline of the rolling mill, an annular driving bevel gear of a large diameter for driving and rotating the rolls, an input-shaft mechanism for rotating the driving bevel gear, a plurality of transmission mechanisms disposed at regular intervals along the driving bevel gear, and a housing for holding them. The input-shaft mechanism (i) has an input shaft inserted in the housing from its outside and an input bevel gear of a small diameter mounted on the input shaft and engaging with the driving bevel gear and (ii) is disposed between two adjacent transmission mechanisms. With the input shaft disposed horizontally, the phase angle of the roll unit can be adjusted minutely.

Rolling mill and rolling-mill train

The present invention is to provide a benzenesulfonic acid salt and a benzoic acid salt of (S)-4-&lsqb;4-&lsqb;(4-chlorophenyl) (2-pyridyl)methoxy&rsqb;piperidino&rsqb;butanoic acid represented by the formula (I):

Acid-addition salts of optically active piperidine compound and process for producing the same

A rolling mill comprising a roll unit and a drive unit for driving the roll unit. The drive unit comprises an outer housing, a pair of large-diameter ring-like driving bevel gears disposed concentric with the pass line, an input shaft mechanism for rotating the driving bevel gears, and transmission mechanisms for transmitting the torque of the driving bevel bears to the rolls. Each transmission mechanism comprises a small-diameter transmission bevel gear caught between and engaging with the driving bevel gears and first and second transmission shafts for transmitting the torque of the transmission bevel gear to a roll. The drive and roll units are coupled and uncoupled by couplings. Four positioning parts are formed on the outer periphery of the inner housing of the roll unit. The outer housing of the drive unit is generally in the shape of a ring, and four positioning parts are formed on the inner periphery of the outer housing. When the inner housing is fitted into the outer housing, the inner housing is positioned in the outer housing by the positioning parts laterally and longitudinally and also in both directions of the pass line by stoppers and hold-downs.

Rolling mill

Pyrrolopyridazine derivatives having the general formula. ##STR1## In the above formula, R.sup.1 represents a C.sub.2 -C.sub.6 alkenyl-group, a halogeno-C.sub.2 -C.sub.6 -alkenyl group, a C.sub.6 -C.sub.10 aryl-C.sub.2 -C.sub.6 -alkenyl group, a C.sub.2 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.3 -C.sub.7 cycloalkyl-C.sub.1 -C.sub.6 -alkyl group, a C.sub.5 -C.sub.7 cycloalkenyl-C.sub.1 -C.sub.6 -alkyl group or a halogeno-C.sub.1 -C.sub.6 -alkyl group; R.sup.2 and R.sup.3 are the same or different and each represents a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a C.sub.6 -C.sub.10 aryl group; R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; R.sup.5 represents a C.sub.6 -C.sub.10 aryl group or a 5-10 membered heteroaryl group comtaining heteroatom(s) selected from nitrogen, oxygen and sulfur;

Pyrrolopyridazine derivatives

Arylamino pyrimidine compound

Quinoline derivative

Disclosed is a diarylmethoxypiperidine compound represented by the formula (I): ##STR1## wherein Ar.sup.1 and Ar.sup.2 each represent a phenyl group which may be substituted by a specific substituent, or a pyridyl group; X represents an alkylene group or a group having ##STR2## where n represents an integer of 1 to 8; Y represents oxygen atom or a group having --CONH--; and Z represents a phenyl group having at least one specific substituent as defined in the specification; and pharmaceutically acceptable salt thereof.

Diarylmethoxypiperidine derivatives

Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical compositions containing the compound. The compound has an antihistamic and antiallergic effect.

Piperdine and piperazine derivatives, and antihistaminic pharmaceutical

Growing community of inventors

Ube, Japan

Hiroshi Fujiwara