Kuraray Co., Ltd.

Sanyo Chemical Industries, Ltd.

Other

University of Florida Research Foundation, Incorporated

Kabushiki Kaisha Tokai Rika Denki Seisakusho

Tosoh Corporation

Japan Medical Supply Co., Ltd.

Hiroo Iwata

Yoshito Ikada

Waro Taki

Yasuhiro Yonekawa

Sen Yamagata

Takehisa Matsuda

Hajime Handa

Tetsuo Itoh

Masakazu Suzuki

Eugene P Goldberg

Yasuhiro Goto

Hiroaki Nakamura

Haruhiko Kikuchi

William E Longo

Yoshiyuki Miyaki

A method for modifying the surface of a polymer article, which comprises applying to the polymer article a macromer having a radical polymerizable double bond, followed by treatment with non-polymerizable plasma.

Method for modifying the surface of a polymer article

An apparatus for separating a balloon from a catheter member of a balloon is capable of melting and breaking a heat-meltable connecting member through which the balloon is connected to the catheter body by causing an electric current to flow between at least a pair of electrodes arranged on or in the vicinity of the connecting member. The apparatus has impedance measuring means for measuring the impedance of an electrode circuit including a pair of electrodes and lead lines connected to the electrodes, and judging means for comparing the measured value of the impedance with a predetermined reference range and capable of producing an abnormal signal when the measured value of the impedance does not fall within the predetermined reference range. The apparatus enables the operator to judge whether the electrode circuit is in safe condition, before changing the balloon with a settable liquid and to charge a settable liquid into the balloon only when the safe condition of the electrode circuit is confirmed, so that the balloon after the setting of the liquid can be separated from the catheter body without fail, thus eliminating any risk for the catheter body to dangerously remain in the living body.

Method of and apparatus for separating a balloon in a balloon catheter

Elastomeric or flexible surgical adhesives, comprising [A] NCO-terminated hydrophilic urethane prepolymer derived from hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polymerizable double bond, are used for bonding of tissues, with rapid cure rate and sufficient bonding power.

Surgical adhesive

A highly blood-compatible material comprising a polymeric base material and water-soluble and substantially nonionic polymer(s) directly attached to the surface of the base material in an amount of 1 to 100 .mu.g/cm.sup.2. The polymeric base material is preferably in the form of a web and composed of polyurethane, ethylene/vinyl acetate copolymer or polyvinylchloride. In addition, the attached polymers may be selected from the group consisting of acrylamide polymers, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, and dextran. This material is particularly useful for preparing vascular prosthesis of small diameters.

Polymer materials for vascular prostheses

Novel hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide in an organic solvent solution of a high molecular weight polymer to form a stabilized dispersion of microspheres and cross-linking said microspheres with a polyfunctional cross-linking agent.

Microspheres for incorporation of therapeutic substances and methods of

This invention provides a releasable balloon catheter having a portion cuttable by torsion or a portion cuttable by heating at or near a joint part between the catheter body and the balloon. When the balloon catheter is inserted into a vessel and carried to the desired site by the blood stream and the balloon is inflated by introducing a fluid into the balloon and is fixed at the desired site face-to-face with the wall of the vessel, torsion or heating causes the balloon to be released from the catheter body. The balloon catheter is used to embolize vascular lesions.

Releasable balloon catheter

This invention provides a releasable balloon catheter having a tube cuttable by torsion or a tube cuttable by heating at a joint part between the catheter body and the balloon. When the balloon catheter is inserted into a vessel and carried to the desired site by the blood stream and the balloon is inflated by introducing a fluid into the balloon and is fixed at the desired site face-to-face with the wall of the vessel, torsion or heating causes the balloon to be released from the catheter body. The balloon catheter is used to embolize vascular lesions.

Disclosed is a balloon catheter including a catheter and a balloon bonded to the catheter through an adhesive in which the outer surface of the balloon is contiguous to the outer surface of the catheter through a smooth surface. In this balloon catheter, the balloon is tightly fixed to the catheter and there is no risk of separation of the balloon. Further, since the balloon catheter has a smooth surface in the connecting portion, insertion of the balloon catheter into a blood vessel and withdrawal of the balloon catheter from the blood vessel can be performed very easily and smoothly. Accordingly, this balloon catheter can be used very advantageously for the angiography.

Growing community of inventors

Suita, Japan

Hiroo Iwata