Denki Kagaku Kogyo Kabushiki Kaisha

Hironoshin Kitagawa

Hiroshi Kaneko

Kazuhiko Arai

Toshihiko Umeda

Teruzou Miyoshi

Yoshiaki Ishimatsu

Shigeki Shigesada

Osamu Yamamoto

Akio Okamoto

Masamichi Hashimoto

Masatoshi Kawata

Yoshiaki Miyata

Hitoshi Ikeya

Shoji Kimura

Teruzo Miyoshi

Kazuhiro Ohshima

Haruhisa Saegusa

Susumu Chiba

Toshio Mihara

Production of a hyaluronic acid gel, which comprises keeping hyaluronic acid in water at a hyaluronic acid concentration of at least 5 wt % in the presence of an acid component in an amount at least equimolar with the carboxyl groups in the hyaluronic acid.

Hyaluronic acid gel, process for producing the same, and medical material containing the same

A gel made of hyaluronic acid alone which is hardly soluble in a neutral aqueous solution and has fluidity enough to be easily ejectable from an injector.

Hyaluronic acid gel, process for the preparation thereof and medical materials containing the same

An agent for treating a skin disease selected from the group consisting of a contact dermatitis treating agent, a xerosis senilis treating agent, an asteatosis treating agent, a housewives eczema treating agent, a keratosis treating agent, an eczema chronicum treating agent, a miliaria treating agent and a diaper rash treating agent, which contains hyaluronic acid and/or its salt having an average molecular weight of from 800,000 to 4,000,000, as an active ingredient.

Hyaluronic acid and its salt for treating skin diseases

A method for producing sodium hyaluronate by a fermentation method comprises culturing a mutant strain FM 100 derived from Streptococcus equi and partially free from auxotrophy to thereby stably produce sodium hyaluronate and accumulating the hyaluronate. A method for producing sodium hyaluronate by a fermentation method comprises culturing a mutant strain FM 300 derived from Streptococcus equi and partially free from auxotophy to thereby stably produce sodium hyaluronate and accumulating the hyaluronate.

Method for producing sodium hyaluronate by fermentation method

A process for producing an immobilized enzyme composition comprises simultaneously reacting a non-proteolytic enzyme and a water soluble-multifunctional reagent with a non-hardened granular gelatin in an aqueous medium wherein the reacting is carried out in the presence of a water-soluble protein polymer compound in an amount of from 0.01 to 2 parts by weight relative to one part of the non-proteolytic enzyme. The non-proteolytic enzyme forms a uniform film on the surface of the granular gelatin and the bond between the non-proteolytic enzyme and the granular gelatin is strengthened by the water soluble protein polymer.

Immobilization of enzymes on granular gelatin

Immobilized enzyme compositions for industrial use are produced by reacting an enzyme and/or enzyme-containing microorganism cells with an anion-exchange high molecular substance having a quaternary pyridine ring in the molecule, and then subjecting the reaction products to molding and drying in a molding machine. A polyfunctional crosslinking agent may be added at any stage of the process. The immobilized enzyme compositions thus prepared can be packed in a reactor of an industrial scale for continuous enzyme reaction.

Process for producing immobilized enzyme compositions

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Machida, Japan

Hironoshin Kitagawa