Maruishi Pharmaceutical Co., Ltd.

Hironori Nagahara

Yutaka Itsuji

Keisuke Jinbo

Mai Nomura

Yuko Itsuji

The present invention provides a rocuronium preparation with an excellent stability. The rocuronium preparation contains rocuronium and a buffer solution and having an adjusted pH of 3.5 or less (for example, 2.5 to 3.5). The buffer solution may be a citric acid-sodium hydroxide buffer solution, a tartaric acid-sodium hydroxide buffer solution, a potassium hydrogen phthalate-hydrochloric acid buffer solution, a glycine-hydrochloric acid buffer solution, or the like. Such a rocuronium preparation has, for example, after 6-month storage at 40&#xb0; C., a generation rate of rocuronium-related substance C of 5% or less.

Rocuronium preparation with improved stability

Provided is an agent for stabilizing acetaminophen in an aqueous composition, the agent comprising glycine. The agent further comprising at least one kind of sulfurous acid salt selected from the group consisting of sodium sulfite, potassium sulfite and potassium pyrosulfite is more effective. The stabilizing includes preventing precipitation.

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Osaka, Japan

Hironori Nagahara