Tanabe Seiyaku Company, Limited

Hironori Kurita

Toru Otake

Haruyo Mori

Motoko Morimoto

Tamon Moriya

Kohki Takashima

Mitsutaka Kawazu

Disclosed is a polysulfate of a .beta.-cyclodextrin in which at least one of 7 D-glucose units constituting the .beta.-cyclodextrin is a unit represented by the formula (I-a): ##STR1## wherein R.sup.1 is an alkyl group having 1 to 8 carbon atoms, a lower alkyl group having a substituent(s) or a lower alkenyl group, or a salt thereof, which has excellent antiretrovirus activity and is useful as an antiretrovirus agent.

Polysulfate of .beta.-cyclodextrin derivative and process for preparing

A polysulfate of a cyclodextrin in which at least one of 6 to 8 D-glucose units constituting the cyclodextrin has been replaced by a unit represented by Formula(1): ##STR1## wherein R is a group represented by the formula: ##STR2## where R.sup.1 to R.sup.7 are defined in the specification, which have an excellent antiretrovirus activity, particularly an excellent proliferation-inhibiting activity against HIV.

Polysulfate of cyclodextrin derivative and process for preparing the same

A polysulfate of a cyclodextrin in which at least one of 6 to 8,D-glucose units constituting the cyclodextrin has been replaced by a unit represented by Formula (1): ##STR1## wherein R is a group represented by the formula: ##STR2## where R.sup.1 to R.sup.7 are defined in the specification, which have an excellent antiretrovirus activity, particularly an excellent proliferation-inhibiting activity against HIV.

A compound of the formula: ##SPC1## Wherein R.sup.2 is mesitylsulfonyl or 2,4,6-triisopropylbenzenesulfonyl and n is an integer of 6 or 7, is reacted with a compound of the formula:

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Hironori Kurita