Toyama Chemical Co., Ltd.

Taisho Pharmaceutical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Hironori Kotsubo

Kenji Yonezawa

Masato Takahashi

Hisaaki Chaki

Tamotsu Takamatsu

Hiroki Urabe

Taro Kiyoto

Tetsuya Yabuuchi

Minako Yotsuji

Kazuya Hayashi

Hajime Takashima

Yukihiko Aikawa

Yusuke Oka

Shunichi Shiozawa

Shuichi Hirono

Muneo Shoji

Fumito Uneuchi

Yasuko Kawaguchi

Katsuji Ojima

Hirohiko Yamamoto

Risa Tsuruta

Kyoko Taya

Minoru Yamada

Shoichi Hamamoto

Hiroko Matsukura

Kazuko Takaoka

Yoichiro Suga

Tadashi Tanaka

Yasutaka Baba

Yukie Tada

Tadakazu Takakura

Keiichi Tsuchida

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. 

Hydroxamic acid derivative

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof: 

The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3&#xb0; and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0&#xb0; on 2&#x3b8; of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.

Crystal of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid

A benzophenone derivative represented by the following formula: wherein

Benzophenone derivatives or salts thereof

A compound or a salt thereof having the atom corresponding to Nand the two or more atoms selected from N, N, Nand N, said atoms constitute the pharmacophore represented by the following formula: 

Compounds and medicinal use thereof

PROCESSES FOR PRODUCING 7-ISOINDOLINE-QUINOLONECARBOXYLIC ACID DERIVATIVE AND ITS INTERMEDIATE, AS WELL AS SALT OF 7-ISOINDOLINE-QUINOLONECARBOXYLIC ACID DERIVATIVE, ITS HYDRATE AND COMPOSITION COMPRISING THE SAME AS ACTIVE INGREDIENT

Processes for producing 7-isoindolinequinolonecarboxylic derivatives and intermediates therefor, salts of 7-isoindolinequinolonecarboxylic acids, hydrates thereof, and composition containing the same as active ingredient

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Toyama, Japan

Hironori Kotsubo