Otsuka Pharmaceutical Company, Limited

Hironobu Ishiyama

Kunio Oshima

Takumi Sumida

Nobuaki Ito

Tomoichi Shinohara

Takeshi Kuroda

Masatoshi Chihiro

Isao Takemura

Takahiro Tomoyasu

Tae Fukushima

Takahito Yamauchi

Kazuhide Ohta

Hideki Kitagaki

Junpei Haruta

Hidetaka Hiyama

Yoko Sakamoto

Hitoshi Nagao

Kenji Watanabe

Hideki Kawasome

Kazuhiko Fujita

Chiharu Kitajima

Masaaki Takano

Hisanobu Hirano

Yasushi Ohkubo

Kenjiro Sasaki

The present invention relates to stem cells obtained by culturing monocytes in the presence of (i) M-CSF and (ii) at least one member selected from the group consisting of ganglioside and water-soluble plant-derived extract, thereby dedifferentiating the monocytes; a therapeutic agent for treating damaged cells, tissues or organs; a cell drug agent; a method of producing stem cells, a culture medium for dedifferentiating monocytes; a dedifferentiation inducing agent; a cell drug kit; a kit for producing dedifferentiated cells; and a pharmaceutical composition.

Stem cell for therapeutic use which is derived from human monocyte, and method for inducing same

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): 

Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-&#x3b1;, and IL-4

The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; Rand Reach represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; Ris a hydrogen atom, etc; Ris a hydrogen atom, etc; and Ris a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

Carbostyril compound

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) &#x2014;CO&#x2014;B&#x2014; wherein B is a Calkylene group and (ii) &#x2014;CO&#x2014;Ba&#x2014; wherein Ba is a Calkenylene group, and include optical isomers and salts of the compounds.

Thiazole compound and use thereof

Growing community of inventors

Tokushima, Japan

Hironobu Ishiyama