Wako Pure Chemical Industries, Inc.

Shiono Chemical Co., Ltd.

Canon Kabushiki Kaisha

Ajinomoto Co., Ltd.

Rhodia Operations

Jnc Corporation

Japan Energy Corporation

N.e. Chemcat Corporation

Sng Inc.

Hironao Sajiki

Yasunari Monguchi

Kosaku Hirota

Yoshinari Sawama

Tsuneaki Maesawa

Nobuhiro Ito

Kazushige Muto

Kwihwan Park

Shinichi Kondo

Miki Itoh

Tsuyoshi Yamada

Miki Niikawa

Hiroyuki Morita

Yoshiaki Isobe

Haruo Takaku

Riichi Miyamoto

Hongzhi Bai

Nobuyoshi Chiba

Kohsaku Hirota

Hayato Masuda

Tomohiro Matsuo

Yasushi Sasai

Tomohiro Ichikawa

Yutaka Kobayashi

Hiroyuki Kitayama

Tomohiro Maegawa

Masahiro Mizuno

Kaori Tsuruoka

Toshiyuki Kawanabe

Shinichi Furusato

Aya Ogawa

Yoichi Ohba

A hydrocarbon is produced by applying mechanical energy to a metal body containing stainless steel by solid-solid contact so that a contact pressure per unit area is 30 kPa or more, in the presence of a gas containing carbon dioxide and a hydrogen source, thereby adding hydrogen to carbon dioxide. Further, a hydrocarbon is produced by providing a reaction vessel for applying mechanical energy to a metal body by solid-solid contact in the presence of a gas containing carbon dioxide and a hydrogen source, a gas introduction unit for introducing the gas containing carbon dioxide to the reaction vessel, a hydrogen source introduction unit for introducing the hydrogen source to the reaction vessel, and a gas discharge unit for discharging a gas containing the hydrocarbon produced in the reaction vessel, and adding hydrogen to the carbon dioxide in the reaction vessel.

Method of producing hydrocarbon and apparatus for producing hydrocarbon

Provided is a process in which a cyclobutanediol compound having a high cis:trans ratio can be stably obtained. The cyclobutanediol compound having a cis:trans ratio of 1.5:1 to 5000:1 is produced by using at least one compound selected from a group consisting of a cyclobutanedione compound, a cyclobutane ketol compound, and a cyclobutanediol compound as a raw material, and performing a catalytic hydrogenation reaction and an isomerization reaction in the cyclobutanediol compound in a solid phase state in the presence of a metal catalyst without adding a solvent.

Method for producing cyclobutanediol compound

A catalyst includes a carrier, and a metal obtained by reducing a metal ion supported on the carrier 1) in a supercritical state or 2) in a polar organic solvent, wherein the carrier is an inorganic porous body having a hierarchical porous structure. By employing the catalyst, it is possible to exhibit better catalytic activity than a conventional catalyst. Heat generation and spontaneous ignition are prevented because no organic porous body is used.

Catalyst in which metal is carried on inorganic porous body having hierarchical porous structure, and method for manufacturing said catalyst

The present invention provides a method of efficiently deprotecting a protected organic compound by catalytic hydrogenation. Specifically, the present invention provides a method of deprotecting an organic compound having at least one functional group selected from the group consisting of a carboxy group, an amino group and a hydroxy group, which is protected by a protecting group represented by the formula (I):R&#x2014;C(R)(R)-L-&#x2003;&#x2003;(I)[wherein Ris an aryl group optionally having substituent(s), Rand Rare each independently, a hydrogen atom or an aryl group optionally having substituent(s), and Lis a single bond, &#x2014;O&#x2014;CO&#x2014; or &#x2014;O&#x2014;CH&#x2014;], comprising hydrogenation in the presence of a metal catalyst and halogenated acetic acid.

Deprotection method

An object is to provide a process for providing hydrogen or heavy hydrogens conveniently without the necessity of large-scale equipment and a process capable of performing hydrogenation (protiation, deuteration or tritiation) reaction conveniently without the use of an expensive reagent and a special catalyst. The production process includes a process for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, and a process for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, containing subjecting an organic compound and water or heavy water to mechanochemical reaction in the presence of a catalyst metal.

Process for producing hydrogen or heavy hydrogens, and hydrogenation (protiation, deuteration or tritiation) of organic compounds using same

Objects are to provide efficient methods for producing hydrogen or heavy hydrogens and for hydrogenating (protiating, deuterating or tritiating) an organic compound, and to provide an equipment and the like used therefor. A method for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, in which an energy density of a rotational acceleration of 75 G or more is applied to water or heavy water for 25 minutes or more, a method for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, a method for hydrogenating (protiating, deuterating or tritiating) an organic compound, a method for dehalogenating an organic compound having halogen, and a ball for mechanochemical reaction are provided.

Method for producing hydrogen or heavy hydrogens, method for producing hydrogenated (protiated, deuterated or tritiated) organic compound, method for hydrogenating (protiating, deuterating or tritiating) organic compound, method for dehalogenating organic compound having halogen, and ball for use in mechanochemical reaction

The subject of the present invention is to provide a method for deuteration, which can obtain a compound having an aromatic ring and/or a heterocyclic ring at an improved deuteration ratio. The present invention relates to a method for deuteration of a compound having an aromatic ring and/or a heterocyclic ring, comprising reacting the compound having an aromatic ring and/or a heterocyclic ring with a heavy hydrogen source in the presence of an activated mixed catalyst of not less than two kinds of catalysts selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, an iridium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.

Method of deuteration using mixed catalyst

A method for producing a polyamine is described that provides excellent safety, a lot of flexibility regarding a variety of its productions, and that can produce a polyamine of high-molecular weight easily and inexpensively. The polyamine includes a combination of units of formula (1) or (2):&#x2014;(NH&#x2014;(CH)&#x2014;NH&#x2014;(CH))&#x2014;&#x2003;&#x2003;(1)(in the formula (1), independently in every unit, 'm' indicates an integral number of 0 or more and 'n' indicates an integral number of 3 or more.)&#x2014;(NH&#x2014;y&#x2014;NH &#x2014;Z)&#x2014;&#x2003;&#x2003;(2)(in the formula (2), independently in every unit, &#x201c;Y&#x201d; and &#x201c;Z&#x201d; are the same as or different from each other, and they indicate substituted or unsubstituted groups including unsaturated aliphatic, cyclic aliphatic or aromatic hydrocarbon radicals that can include hetero atoms.).

Polyamine and method for producing thereof

The present invention relates to a method for deuteration of a compound having an aromatic ring, using an activated catalyst, and the method comprises reacting a compound having an aromatic ring with heavy hydrogen source in the presence of an activated catalyst selected from a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.

Method for deuteration of an aromatic ring

A functional group-selective hydrogenation catalyst is provided, which is capable of selectively hydrogenating an aliphatic carbon-carbon double bond, aliphatic carbon-carbon triple bond, aromatic formyl group or aromatic nitro group contained in an organic compound. The catalyst includes a carrier, and palladium and an organic sulfur compound supported jointly thereon.

Functional group-selective hydrogenation catalyst and functional group-selective hydrogenation method

The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.

Method for deuteration of a heterocyclic ring

The present invention relates to a method for deuteration of an inert alkane using activated palladium carbon. The present invention discloses 'A method for deuteration of a hydrogen atom of a methyl group or a hydrogen atom bonded to a carbon atom at benzyl position and the other carbon atoms of an alkylene group having not less than 2 carbon atoms, in a compound containing the methyl group or the-alkylene group having not less than 2 carbon atoms, directly bonded to an aromatic ring which may have a substituent, which comprises placing said compound in a deuterated solvent in the presence of activated palladium carbon, under sealed reflux condition'.

Method for deuteration of an inert methylene

The present invention relates to a pyrazole derivative represented by formula (I) or (II) ##STR1## wherein R.sup.1 is hydrogen C2-C6 alkyl benzyl or phenyl; each of R.sup.2 and R.sup.3 is hydrogen, C1-C6 alkyl or benzyl; each of R.sup.4 and R.sup.5 is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl, benzyl or phenyl;

Pyrazole derivatives and their pharmaceutical use

Growing community of inventors

Gifu, Japan

Hironao Sajiki