Taisho Pharmaceutical Co., Ltd.

The Green Cross Corporation

Tosoh Corporation

Hironaka Aihara

Kazumasa Yokoyama

Tadakazu Suyama

Yutaka Mizushima

Hiroyuki Okamoto

Susumu Otomo

Kazuyuki Tomisawa

Katsuo Komiya

Hiroo Sasaki

Yumiko Asami

Michio Kurachi

A method for lowering serum total cholesterol in an animal by administering to the aminal an anion-exchange resin having the monomer units respectively represented by the below-given structural formulas (I), (II), (III) and (IV) in a content of 60-95 molar % of the monomer unit (I), 0-25 molar % of the monomer unit (II), 0--30 molar % of the monomer unit (III) and 1-6 molar % of themonomer unit (IV). ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 which may be the same or different respectively are hydrogen atom, a lower alkyl group or benzyl group, R.sup.4 is hydrogen atom, a lower alkyl group or hydroxy-methyl group and X is a halogen atom. The above-mentioned agents specifically bind with bile acid in the intestinal tract even in the presence of other acids.

Cholesterol-lowering agents

A cinnamamide derivative represented by the formula ##STR1## wherein X is a halogen atom is useful as a muscle relaxant.

Pharmaceutical use for cinnamamide derivatives

A fat emulsion containing a prostaglandin E.sub.1 alkyl ester represented by the general formula ##STR1## wherein R denotes an alkyl group having 1 to 30 carbon atoms. The fat emulsion can be administered intravenously, has a long half-life of its effective ingredient, prostaglandin E.sub.1 alkyl ester, in the living body as well as a focus selectivity.

Fat emulsion containing prostaglandin

A fat emulsion for injection containing prostaglandin E.sub.1 which has a vasodilative action as well as a hypotensive action and a method for the production of such an emulsion. The present emulsion is effective in treating chronic arteriostenosis diseases.

Fat emulsion containing prostaglandin E.sub.1 and method for production

Growing community of inventors

Saitama, Japan

Hironaka Aihara