Takeda Chemical Industries, Inc.

Hoffmann-la Roche Inc.

Other

Takeda Chemical Ind., Ltd.

Hiromu Sugino

Susumu Honda

Hsiang-Fu Kung

Yoshio Hayashi

Norihiko Moriya

Atsushi Kakinuma

Hiroki Shouji

Masao Isono

Takanori Nakamura

Screening of the autoantibodies and autoantigens which are specific to Sj&ouml;gren's syndrome, particularly primary Sj&ouml;gren's syndrome, and provision of a prophylactic and therapeutic drug for Sj&ouml;gren's syndrome, particularly primary Sj&ouml;gren's syndrome, and a highly sensitive diagnostic agent for Sj&ouml;gren's syndrome. The &agr;-fodrin or &agr;-fodrin fragment of the invention is an antigen to the autoantibodies specifically found in Sj&ouml;gren's syndrome and this autoantigen finds application as a prophylactic and therapeutic drug for autoimmune diseases, particularly Sj&ouml;gren's syndrome, or a diagnostic agent for such diseases.

Composition containing &agr;-fodrin or &agr;-fodrin fragment protein

To provide a method of isolating and detecting a new receptor gene, as a means of elucidating the function of neuronal cell-specific receptors, especially of elucidating the detailed mechanism of the neuronal cell differentiation inhibitory and nerve nutrition factor-like actions of activin receptors, DNA containing said new receptor gene, a method of producing a protein encoded by this new receptor gene, and use for this DNA and protein. The receptor protein of the present invention and DNA encoding this protein can be used for various purposes, including 1) ligand determination, 2) obtainment of antibodies and antisera, 3) construction of recombinant receptor protein expression systems, 4) development of receptor binding assay systems and screening for pharmaceutical candidate compounds using expression systems, 5) drug designing based on comparison with structurally similar ligand receptors, 6) reagent for preparation of probes and PCR primers for gene diagnosis, and 7) drug for gene therapy.

DNA encoding a neuronal cell-specific receptor protein

Screening of the autoantibodies and autoantigens which are specific to Sjogren's syndrome, particularly primary Sjogren's syndrome, and provision of a prophylactic and therapeutic drug for Sjogren's syndrome, particularly primary Sjogren's syndrome, and a highly sensitive diagnostic agent for Sjogren's syndrome. The .alpha.-fodrin or .alpha.-fodrin fragment of the invention is an antigen to the autoantibodies specifically found in Sjogren's syndrome and this autoantigen finds application as a prophylactic and therapeutic drug for autoimmune diseases, particularly Sjogren's syndrome, or a diagnostic agent for such diseases.

Methods of detecting antibodies to .alpha.-Fodrin and fragments thereof

An intact human immune interferon protein and a method for the extraction and purification of intact recombinant human immune interferon is disclosed. This method permits the purification to homogeneity of intact recombinant human immune interferon.

Recombinant immune interferon having an intact carboxyl terminus

An intact human immune interferon protein and a method for the extraction and purification of intact recombinant human immune interferon is disclosed. This method permits the purification to homogenity of intact recombinant human immune interferon.

Immune interferon

Immune interferon and a method for its extraction and purification

An active fragment of human immune interferon and a method for the extraction and purification of this protein fragment is disclosed. This method permits the purification to homogenity of the active fragment of recombinant human immune interferon.

Homogeneous immune interferon fragment

Process for producing plasminostreptin by cultivating a Streptomyces microorganism.

Growing community of inventors

Hyogo, Japan

Hiromu Sugino