Takara Shuzo Co., Inc.

Takara Bio Inc.

Hiromu Ohnogi

Ikunoshin Kato

Hiroaki Sagawa

Nobuto Koyama

Eiji Kobayashi

Katsushige Ikai

Tatsuji Enoki

Eiji Nishiyama

Hua-Kang Wu

Takanari Tominaga

Michio Hagiya

Suzu Deguchi

Katsumi Sugiyama

Masahiro Shiraga

Hideto Chono

Akihiro Kondo

Nobuko Muraki

Tuo-Ping Li

Yoko Tatsumi

Motoko Ueda

The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In addition, the present invention provides a medicament, a food, a beverage or a feed having a therapeutic or prophylactic effect for a disease showing sensitivity to the compound, by utilizing the physiological actions of the compound.

Chalcone compounds

The present invention relates to a chalcone compound represented by the following general formula: wherein Rand Rare taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where Ris a hydroxyl group, Ris an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.

Chalcone compound

The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

Remedies

The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.

Enhancing agent for nerve growth factor production comprising a compound having a coumarin backbone or a compound having a 2-dimethyl chroman backbone

Substances capable of inducing apoptosis

Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula &lsqb;I&rsqb;, optically active isomers and salts thereof, wherein R and R are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

Remedies or preventives containing cyclopentenone compounds as the active ingredient

Product of heat treatment of uronic acid, food, drink, or drug including the product

5-membered ring compounds

An antirheumatic agent which is characterized in containing at least one compound selected from a group consisting of 4,5-dihydroxy-2-cyclopenten-l-one represented by the following formula &lsqb;I&rsqb; and an optically active substance and a salt thereof as an effective component.

Antirheumatic agents

A compound represented by the following formula &lsqb;I&rsqb; or an optically active substance or a salt thereof.

Compounds

Growing community of inventors

Kusatsu, Japan

Hiromu Ohnogi