Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Hiromitsu Yokohama

Ieharu Hishinuma

Toshihiko Kaneko

Kenzo Muramoto

Norihito Ohi

Mark Spyvee

Seiichi Kobayashi

Kouichi Kikuchi

Motohiro Soejima

Boris M Seletsky

Heather Davis

Wanjun Zheng

Yimin Jiang

André Lescarbeau

Xiang-Yi Li

Bruce Decosta

Fabian Gusovsky

Marc Pesant

Ye Yao

Lynda Tremblay

Yan (Janet) Zhao

Jane Daun

Shinya Abe

Isao Yamatsu

Shigeki Hibi

Katsuya Tagami

Yasushi Okamoto

Takashi Yamanaka

Junichi Nagakawa

Kazuo Hirota

Kaname Miyamoto

Tsutomu Yoshimura

Koichi Katayama

Yasunori Akita

Tohru Horie

Fumihiro Ozaki

Richard S Clark

Mitsuaki Miyamoto

Tetsuya Kawahara

Kazuo Okano

Naoki Yoneda

Ichiro Yoshida

Atsushi Kamada

Yasutaka Takase

Junichi Kamata

Yoshiaki Ohashi

Yoshinori Sakuma

Shuichi Suzuki

Manabu Shirato

Hidenori Seshimo

Tohru Arai

Masayoshi Ohkuro

Futoshi Miyazaki

Daiya Shimokubo

Osamu Takenaka

Jiro Sonoda

The present invention provides compounds having formula (I): 

Deazapurines and uses thereof

As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

The present invention provides compounds having formula (I), wherein R, R, Rand n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally 

The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y represents phenyl, piperazine, pyridine, thiophene, thiazole, oxathiazole or oxathiadiazole; and variables Z, n, R, R, Rand Rare as defined in the claims.

Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof

Benzopiperidine derivatives

A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.

Quinone derivatives and pharmacological use

A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.

Ouinone derivatives and pharmacological use

Growing community of inventors

Moriya, Japan

Hiromitsu Yokohama