The University of Tokyo

Leland Stanford Junior University

Terumo Kabushiki Kaisha

Kaken Pharmaceutical Company, Ltd.

National Federation of Agricultural Coopertive Associations

Nissan Chemical Industries Limited

National Federation of Agricultural Cooperative Associations

Hiromitsu Nakauchi

Koji Eto

Naoya Takayama

Sou Nakamura

Hideki Masaki

Motoo Watanabe

Satoshi Yamazaki

Shin Kaneko

Toshinobu Nishimura

Irving L Weissman

Yuki Taya

Hidekazu Nishiki-I

Takahiko Murata

Tetsuya Ito

Shinya Yamanaka

Kazutoshi Takahashi

Shinya Sano

Tomoyuki Yamaguchi

Hideyuki Sato

Yutaka Sendai

Hideyuki Murayama

Sanae Hamanaka

Naoaki Mizuno

Mai Kamikawa

Kazuo Fukawa

Hiroko Tsukui

Ryoko Ohnishi

Tomohiro Ishigaki

Kayoko Tsuji

According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.

Method for reconstructing immune function using pluripotent stem cells

The present invention has found that chimeric animals suffer from noticeable inflammation after birth, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.

Finding and treatment of inflammation after birth in chimeric animal

The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.

Method for producing chimeric animal

The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal at a high percentage is sustained for a long period of time. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified, The gene that acts on the hematopoietic system is, for example, Lnk gene, When a medium to large mammal is used as a recipient, the survival rate of hematopoietic cells originating in a heterologous animal is dramatically increased such that blood chimerism of 10% or more can be maintained even in a 16 month old animal.

Method for producing blood chimeric animal

A nutrition formulation, which is substantially free of at least one of valine and methionine and which is capable of parenteral or enteral administration. The nutrition formulation supplies sufficient nutrients to sustain life for at least three weeks by successive administration. A composition containing the nutrition formulation can be used for treating adult cell leukemia/lymphoma.

Composition for treating adult T cell leukemia/lymphoma and method for producing same

[Problem to be Solved] The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. [Solution] The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.

An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.

Method for producing polyploidized megakaryocyte and platelets

Problem to be Solved The present invention provides a technique replacing radiation exposure in decreasing or eliminating hematopoietic stem cells in an animal (particularly human) body. Solution A parenteral nutrition formula or an enteral nutrition formula substantially free of valine.

Composition for decreasing hematopoietic stem cells, and method for producing same

The present invention provides a method for putting a primed pluripotent stem cell in a less differentiated state, a method for producing a pluripotent stem cell having an improved chimera forming ability from a primed pluripotent stem cell, and a method for producing a chimeric animal by using the pluripotent stem cell obtained by any of these methods. The present invention also provides a composition containing a Wnt/&#x3b2; catenin signal inhibitor.

Method for producing pluripotent stem cell having improved chimera forming ability from primed pluripotent stem cell, and composition and combination therefor

The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.

Method for producing differentiated cells

A composition for maintaining a function of platelets, the composition comprising, as an active ingredient, a compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: wherein

Composition for maintaining function of platelets

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Tokyo, Japan

Hiromitsu Nakauchi