Tokyo Metropolitan Institute of Medical Science

Other

Sankyo Company, Limited

Tokyo Metropolitan Organization for Medical Research

Central Institute for Experimental Animals

Japan Poliomyelitis Research Institute

Hiromichi Yonekawa

Choji Taya

Takaji Wakita

Izumu Saito

Michinori Kohara

Tatsuji Nomura

Shinobu Abe

Akio Nomoto

Hajime Karasuyama

Jun-ichi Miyazaki

Hiroshi Shitara

Kunie Matsuoka

Satoshi Koike

So Hashizume

Yoshihiro Ota

A system for observing the behaviors of mitochondria during ontogeny and the dynamics of mitochondria in various tissues during pathological development is provided. A pCAGGS expression vector containing green fluorescent protein (GFP) gene and a transgenic animal characterized by expressing GFP specifically in mitochondria are provided.

GFP expression vector localized in mitochondria

A hepatitis type C animal model into which cDNA derived from hepatitis C virus has been introduced. This animal model is useful for clarification of an onset mechanism of hepatitis C and as well as for development of means for treating the disease.

Hepatitis C animal model

Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under the control of a Cre-loxP switch-expression system. Administration of Cre to the mice results in a phenotype of increased serum GTP levels, emergence of acidophilic bodies in the liver, exfoliation of hepatic cells, hypertrophy and hyperplasia of Kupffer's cells, and conglomeration of lymphocytes.

Transgenic mouse hepatitis C virus model comprising a hepatitis C viral fragment

Transgenic mice which constitutively express an antibody-type molecule encoded by the transgene and which has an IgE heavy chain constant region and is specific for a pre-defined antigen, provide an allergic reaction to that antigen without prior sensitization and are useful as allergy models.

Transgenic animal allergy models and methods for their use

Method for examining neurovirulence of polio virus

Growing community of inventors

Saitama, Japan

Hiromichi Yonekawa