Takeda Pharmaceutical Company Limited

Hiromi Yoshida

Shuji Hinuma

Yugo Habata

Chieko Kitada

Masaki Hosoya

Masaaki Mori

Ryo Fujii

Kazunori Nishi

Makoto Kobayashi

Shoji Fukusumi

Masataka Harada

Shoichi Ohkubo

By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an efficient screening for FPRL1 agonist or FPRL1 antagonist can be performed.

FPRL1 ligands and use thereof

A GPR7 ligand containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:1 wherein the N-terminal amino acid residue may optionally be brominated, is useful in developing a receptor-binding assay system with the use of the GPR7 expression system, in screening a candidate compound for a drug such as an antiobestic, etc.

Ligand of G protein-coupled receptor protein and DNA thereof

The RFRP-3 peptide of the present invention which is an agent for promoting prolactin secretion is useful as a prophylactic and/or therapeutic agent for various diseases associated with prolactin secretion, such as hypoovarianism, seminal vesicle hypoplasia, menopausal syndrome and hypothyroidism.

RFRP-3 and DNA thereof

Growing community of inventors

Ishige-machi, Japan

Hiromi Yoshida