Meiji Seika Kaisha, Ltd.

Meji Seika Kaisha Ltd.

Hiromi Takata

Yasuo Ohtsuka

Kenichi Fushihara

Yumiko Okada

Mami Kawaguchi

Takashi Shishikura

Sohjiro Shiokawa

Toshio Nishizuka

Seiji Tsutsumi

Hideo Kitagawa

Toyoaki Ishikura

Sachiko Miyamoto

Maki Shiobara

Takashi Ando

Yuko Kano

Kazuhiro Aihara

Takahisa Maruyama

Hisashi Suzuki

Takehiko Sawabe

Toshiki Fujita

Nobuyoshi Baba

An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant(PRSP),including bata-lactamase-nonproducing ampicillin-resistant(BLNAR), and(Branhamella) catarrhalis. The present invention provides 2-ethenylthio-based carbapenem derivatives represented by the formula (I) or pharmaceutically acceptable salts thereof that are effective, for example, against pneumococci including penicillin resistant(PRSP),including beta-lactamase-nonproducing ampicillin-resistant(BLNAR), and(Branhamella) catarrhalis: 

2-thioethenyl substituted carbapenem derivatives

Tricyclic triazolobenzazepine derivatives in the form or a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereon. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein Rrepresents hydrogen, OH, alkyl or phenyl alkyl, 

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic agents

A process for preparing a compound represented by formula (IIa')wherein Q represents group (i) as defined in the specification and Rto R, R, R, and Rare as defined in the specification, by (1) reacting a compound represented by formula (V)wherein Rto Rand Rare as defined in the specification. with a compound represented by RRC&#x2550;O wherein Rand Rare as defined in the specification; (2) reacting the compound prepared in (1) with a compound represented by R&#x2014;C(&#x2550;O)&#x2014;Rwherein Rand Reach independently represent a chlorine atom, 4-nitrophenyl, or 1-imidazolyl; and (3) reacting the compound prepared in (2) with a compound represented by ROH wherein Ris as defined in the specification.

Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic

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Yokohama, Japan

Hiromi Takata