Kotobuki Seiyaku Co. Ltd.

Hiromi Baba

Tsuyoshi Tomiyama

Akira Tomiyama

Naoto Ueyama

Takashi Yanagisawa

Motoharu Sonegawa

Tomoyuki Kawai

Makoto Haketa

New therapeutic agent of carboxymethylidenecycloheptimidazole derivatives and method for the manufacture thereof are disclosed, which are represented by the following formula or its alkali addition salts ##STR1## (wherein R.sub.1 represents a lower alkyl; R.sub.2 represents H or isopropyl group; R.sub.3 represent H, a lower alkyl or --C(CH.sub.3)H--OCOOR.sub.4 (R.sub.4 is a lower alkyl or cyclohexyl) and .dbd.CHCOOR.sub.3 is substituted group at 4 or 8 position; A represents ##STR2## These compounds are useful as anti-hypertensive, anti-congestive heart failure agents and intraocular pressure lowering agents.

Carboxymethylidenecycloheptimidazole derivatives, method of

New therapeutic agents of cycloheptimidazole derivatives are disclosed, which are represented by the following formula or its alkali-addition salts. ##STR1## (wherein R.sub.1 represents H or isopropyl group; R.sub.2 represents a lower alkyl; R.sub.3 represents a carboxylic acid or tetrazole group. A and A.sub.1 are substituted groups at 4 or 8 position and A.sub.1 is a hydrogen or hydroxy group when A is a hydrogen or A and A.sub.1 is an oxo group. The dotted line '- - - -' is two double bonds or saturated single bonds). These compounds are useful as anti-hypertensive or anti-congestive heart failure agents.

Cycloheptimidazole derivatives, method of manufacturing the same and

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Ueda, Japan

Hiromi Baba