Meiji Seika Kaisha, Ltd.

Hiromasa Takizawa

Takashi Ida

Katsuyoshi Iwamatsu

Kunio Atsumi

Toshiro Sasaki

Yuko Kano

Kazuhiro Aihara

Takashi Ando

Takahisa Maruyama

Kiyoshi Tanabe

Hideo Kitagawa

Yumiko Sambongi

Yoshihisa Akiyama

Kazuko Kobayashi

Kenichi Fushihara

Yumiko Toyooka

Disclosed is a novel carbapenem derivative having a substituted imidazo&lsqb;5,1-b&rsqb;thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

Carbapenem derivatives

Disclosed is a novel carbapenem derivative having a substituted imidazo&lsqb;5,1-b&rsqb;thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against &bgr;-lactamase producing bacteria, MRSA, resistant- , PRSP, enterococci, and influenza, and high stabilities to DHP-1. According to the present invention, there is provided a compound represented by the formula (I), or a pharmacologically acceptable salt thereof or an ester at the 3-position on the carbapenem ring thereof:

The carbapenem derivatives represented by the following formula (I) is disclosed. These compounds have strong anti-bacterial activities against bacteria including methicillin resistant,, penicillin resistant,, Enterococci, influenza, and &bgr;-lactamase producing bacteria, and have high stabilities to DHP-1

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Yokohama, Japan

Hiromasa Takizawa