Abbott Laboratories Corporation

Hiromasa Nakamoto

Andre G Pernet

Naoyasu Ishizuka

Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH cis or C.tbd.C; Y is CH.sub.2 or O; Z is H, OH, CH.sub.3 or CH.sub.2 OH and R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## where R represents a linear, branched or cyclo alkyl group of 3 to 7 carbon atoms; P is a removable protective group and z is H, OP,CH.sub.3 or CH.sub.2 OP. The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

Prostaglandin derivatives

Prostaglandin type compounds of the formula ##STR1## where X is CH.sub.2 --CH.sub.2, CH.dbd.CH or C.tbd.C; Y is CH.sub.2 or O; Z is OH, CH.sub.3 or CH.sub.2 OH, R' is H or loweralkyl and R is a linear, branched or cyclic alkyl group of 3 to 7 carbon atoms, can be prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein R' is hydrogen, R and Z are the same as shown above, and P is a removable protective group. The new compounds are useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

Prostaglandin type compounds of the formula ##STR1## wherein X is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-cis or--C.tbd.C--; Y is CH.sub.2 or O; Q is--CH.sub.2 --CH.sub.2 --or --CH.dbd.CH--; Z is H, OH, CH.sub.3 or CH.sub.2 OH, R is a linear, branched or cyclo alkyl chain of 3 to 7 carbon atoms or certain other moieties, and R' and R'''are H or CH.sub.3. These compounds are prepared by essentially a one-step reaction from a new intermediate of the formula ##STR2## wherein Z, R, R' and Q have the above meaning and P is a removable protective group by condensation with a reactive moiety introducing the entire .alpha.-chain (R'''=CH.sub.3). If desired, the carbonyl function is subsequently reduced to W= --CH(OH)--. The intermediate is useful in making known and new PGEs useful as antihypertensives, gastric acid secretion inhibitors and smooth muscle stimulants.

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Awara, Japan

Hiromasa Nakamoto