Axikin Pharmaceuticals, Inc.

Bayer Aktiengesellschaft

Hiroko Yoshino

Yingfu Li

Norihiro Kawamura

Timothy B Lowinger

Klaus Urbahns

Toshiki Murata

Takashi Yoshino

Toshiya Moriwaki

Kevin Bacon

Takuya Shintani

Noriko Nunami

Keiko Fukushima

Megumi Yamauchi

Tetsuo Kikuchi

Akihiko Watanabe

William Johnston Scott

Muneto Mogi

Martha E Rodriguez

Margaret Ann Popp

Ming Wang

Nagahiro Yoshida

Noriyuki Yamamoto

Takeshi Yura

Toshio Kokubo

Hiroshi Komura

Scott Miller

Timothy Lowinger

Arnel B Concepcion

Makiko Marumo

Gyoonhee Han

Aniko M Redmann

The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.

Arylsulfonamide derivatives for use as CCR3 antagonists in the treatment of inflammatory and immunological disorders

Arylsulfonamide derivatives for use as ccr3 antagonists in the treatment of inflammatory and immunological disorders

A compound of the formula (I)in which Ris &#x2014;OR, &#x2014;SR, &#x2014;SOR, &#x2014;SOR, &#x2014;NHR, or &#x2014;NRR, and R, R, and Rare as defined broadly in the text. Ris H, C-Calkyl, carbamoyl, or an ester group. Ris thienyl, pyridyl optionally substituted by halogen or C-Calkoxy; naphthyl optionally substituted by C-Calkoxy; dioxane fused phenyl; dioxacyclopentane fused phenyl; or optionally substituted phenyl. Y is CH or N. A process for preparing such compounds, pharmaceutical compositions containing such compounds, and a method of treating asthma using them are also disclosed and claimed.

Imidazopyrimidine derivatives and triazolopyrimidine derivatives

Growing community of inventors

Shiga-ken, Japan

Hiroko Yoshino