Meiji Seika Kabushiki Kaisha

Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Meiji Saika Kaisha, Ltd.

Meiji Seika Kaburhiki Kaisha

Hiroko Ogino

Takashi Tsuruoka

Kiyoaki Katano

Fukio Konno

Tomoya Machinami

Seiji Shibahara

Katsuyoshi Iwamatsu

Fumiya Hirano

Yasukatsu Yuda

Tamako Tomomoto

Shinichi Kondo

Shigeharu Inouye

Yasuo Ohtsuka

Mami Kawaguchi

Takashi Shishikura

Seiji Tsutsumi

Motohiro Nishio

Koji Tsuchiya

Takako Iwasaki

Keiko Shito

Megumi Imai

Takashi Yoshida

Masaji Sezaki

Shigeharu Inoue

Satoru Nakabayashi

Kenichi Fushihara

Naoki Yamazaki

Shigeru Hoshiko

Junko Tanaka

Shunzo Fukatsu

Kunio Atsumi

Yasushi Murai

Tsuneo Okonogi

Eiki Shitara

Fumio Kai

Kenji Sakagami

Sohjiro Shiokawa

Naomi Osada

Toshio Nishizuka

Yasuyuki Ichimaru

Shigeharu Inoye

Kenichi Fusihara

Yamazaki Naoki

Jun Nagura

Hiromi Watanabe

Ryoichi Okamoto

Tricyclic benzazepine compounds

Compounds of formulae (II), (III), (IV) and (V) or salts thereof are intermediates for pharmacologically active tricyclic benzazepine and benzothiazepine derivatives, ##STR1## wherein R represents hydrogen, alkyl, phenylalkyl, or a protective group of a triazole ring, R.sup.1 -R.sup.5 represent hydrogen, alkyl, alkenyl, alkoxy, amino, oxim or hydroxyl, and R.sup.41 represents hydrogen, C.sub.1-6 alkyl which may be optionally substituted, or a protective group for a carboxyl group.

Triazole intermediates for tricyclic benzazepine and benzothiazepine

Tricyclic benzazepine and benzothiazepine derivatives

Pyridine derivatives having angiotensin II antagonism

Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;

Azole derivatives and anti-ulcerative composition containing same

A piperidine compound represented by formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4 carbon atoms, a hydroxymethyl group, --CO.sub.2 R.sup.3, or ##STR2## wherein R.sup.3 represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms; R.sup.4 represents a hydroxyl group, a lower alkoxy group having from 1 to 4 carbon atoms or --NR.sup.6 R.sup.7 (wherein R.sup.6 and R.sup.7, which may be the same or different, each represent a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms); and R.sup.5 represents a hydrogen atom, a lower alkanoyl group having from 1 to 4 carbon atoms, or a chlorobenzoyl group; R.sup.2 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, a substituted or unsubstituted benzyl group, or a (2,2,6,6-tetramethylpiperidin-1-yl)ethyl group; and n represents 0 or an integer of 1 or 2, and an antiulcer composition containing said piperidine compound.

Piperidine compounds and antiulcer composition containing the same

Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which

Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition

Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

Cephalosporin compounds and antibacterial agents

Disclosed is a novel cephem compound which is either one of a cis- or trans-isomer or a mixture of the cis-and trans-isomers, represented by the following general formula (I) and a pharmacologically acceptable salt thereof: ##STR1## wherein all of the substituents are as defined hereinbefore. Also disclosed are a process for producing the above compound and its use as an anti-bacterial agent comprising the same.

Cephem compounds and anti-bacterial agent

This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.p B wherein p is 0 or an integer of 1-3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or, when m is 0, is alkyl of 1-5 carbon atoms, which may optionally be substituted by halogen, alkenyl, a group ##STR6## wherein R.sup.8 is hydrogen, alkyl of 1-4 carbon atoms or phenyl, or cyclopropyl, and a salt thereof.

Cephalosporin derivatives

Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):

Cephalosporin derivatives and bactericides containing the same

Growing community of inventors

Yokohama, Japan

Hiroko Ogino