Kabushiki Kaisha Toshiba

Tokyo Medical and Dental University

Japan Science and Technology Agency

National Institute for Materials Science

Tokai National Higher Education and Research System

Nitta Gelatin Inc.

Hiroko Matsumoto

Akira Matsumoto

Yuji Miyahara

Miyako Tanaka

Takayoshi Suganami

Junzo Tanaka

Masanori Kikuchi

Kazuo Takakuda

Tatsuyuki Mikami

Yoshinobu Mandai

Yoshihisa Koyama

Yuki Morooka

Noriichi Ito

A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.

Temperature-resistant sugar-responsive gel

An improved device capable of releasing a drug in response to stimuli such as a glucose concentration is provided. Provided is a drug delivery device, including a porous body such as a hollow fiber having biocompatibility and drug permeability, a stimuli-responsive gel composition filling inside of the porous body, and a drug surrounded by the gel composition inside of the porous body.

Drug delivery device

This invention relates to a method for regulating the biodegradability of composite biomaterials comprising calcium salt (particularly hydroxyapatite) and collagen, improved composite biomaterials obtained via such method, and a method for increasing bone mass with the use of such composite biomaterials.

Regulation of biodegradability of composite biomaterials

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Tokyo, Japan

Hiroko Matsumoto