Pfizer Corporation

Hiroko Masamune

Anthony Marfat

James F Eggler

Lawrence S Melvin, Jr

Bingwei Vera Yang

Wei-Guo Su

Takushi Kaneko

Yong-Jin Wu

Allen Jacob Duplantier

Edward F Kleinman

Robert William Scott

Katherine E Brighty

Paul R McGuirk

Michael Paul DeNinno

Robert G Linde, Ii

Vinod Dipak Parikh

A agonists, methods of using such A agonists and pharmaceutical compositions containing such A agonists. The A agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia.

Compounds for the treatment of ischemia

This invention relates to compounds of the formula

C-4 substituted macrolide antibiotics

This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.

C-4' substituted macrolide antibiotics

This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDE.sub.IV and in the treatment of AIDS, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases. This invention also relates to pharmaceutical compositions comprising the compounds hereof. ##STR1##

Catechol diethers as selective PDE.sup.IV inhibitors

Antiviral thiazoles

The present invention relates to novel substituted oxindoles of the formula I as defined below and related compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds as inhibitors of phosphodiesterase ('PDE') type IV. The compounds of this invention are useful in the treatment of AIDS, asthma, rheumatoid arthritis, osteoarthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, atopic, dermatitis, shock, other inflammatory diseases, and other conditions where the action of phosphodiesterase type IV is implicated.

Substituted oxindoles

Substituted sulfonamides and related compounds in the treatment of

Substituted chromans and their use in the treatment of asthma, arthritis

Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related

Growing community of inventors

Noank, CT, United States of America

Hiroko Masamune