Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Hiroko Kobayashi

Masanobu Shinoda

Hiroshi Tanaka

Shuichi Suzuki

Motoji Kogushi

Mitsuaki Miyamoto

Tetsuya Kawahara

Fumihiro Ozaki

Richard S Clark

Kazuo Okano

Nobuaki Sato

Akiharu Kajiwara

Ieharu Hishinuma

Itaru Tsukada

Fumiyoshi Matsuura

Atsushi Kamada

Makoto Kotake

Taro Terauchi

Toshiyuki Matsuoka

Yoshimitsu Naoe

Osamu Ito

Akifumi Kimura

Naoto Ono

Ken-ichi Chiba

Yoshiaki Oohashi

Syuhei Miyazawa

Kenji Hayashi

Nobuhisa Watanabe

Tsutomu Kawata

Toru Horie

Issei Ohtsuka

Hironobu Hiyoshi

Takashi Musha

Koichi Nose

Takashi Musya

Toshie Yamada

Motoji Kokushi

Tsutomu Kawada

Ken-Ichi Chiba

Keni-Ichi Chiba

Takashii Musha

A cyclic amidine derivative represented by the formula: [wherein R, Rand Rrepresent hydrogen, Calkyl, aryl-Calkyl, etc.; R, Rand Rrepresent hydrogen, Calkyl, etc.; Z represents 0 or 1; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; n represents 1 or 2; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; Ar represents hydrogen, a group represented by the formula: [wherein R-Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.]or a salt thereof.

Cyclic amidine derivatives

A 2-iminoimidazole derivative represented by the formula: {wherein R, Rand Rrepresent hydrogen, optionally substituted Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2013;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.

2-iminoimidazole derivatives (2)

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R&#x2013;Rrepresent hydrogen, halogen, Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkoxy-Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2014;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc.; and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocyclic ring], etc.},or a salt thereof.

2-iminopyrrolidine derivatives

Benzene derivatives and method of treating arteriosclerosis with benzene

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Tsuchiura, Japan

Hiroko Kobayashi