Nof Corporation

Calsonic Kansei Corporation

Mitsumi Electric Company Ltd.

Tokyo Institute of Technology

Oncotherapy Science, Incorporated

Massachusetts Institute of Technology

Chiba University

Calsonic Corporation

Universitá Degli Studi Di Padova

Marelli Cabin Comfort Japan Corporation

Hiroki Yoshioka

Yuji Yamamoto

Naohisa Kamiyama

Takeshi Ogasawara

Midori Hirai

Nobuhiro Nishiyama

Masaki Kamiya

Daiju Suzuki

Toshio Ohashi

Hiroyasu Takemoto

Takeshi Satoh

Takahiro Nomoto

Makoto Matsui

Yoshitoshi Noda

Tadayoshi Tajima

Hiroyuki Yamaguchi

Kazuki Osakama

Yusuke Nakamura

Toshiharu Watanabe

Yasuhito Okawara

Keigo Endo

Shinji Yamamoto

Kenji Sakanoue

Kaoru Kamiyama

Kota Tange

Keishiro Tomoda

Takashi Otsuka

Mika Hamura

Fumiaki Manabe

Ken Hamura

Akiko Sasaki

Yasuhiro Shiba

Pohsing Ng

Takashi Matani

Hitoshi Nakatsuhara

Kazuki Miyauchi

Elazer Reuven Edelman

Ryuji Ohsawa

Takashi Ootsuka

Takuma Tsubusaki

Ken-ichiro Nakamoto

Yuta Nakai

Hidetaka Akita

Eiji Yamatani

Natalie Artzi

Shuichi Yoshimura

Akira Togashi

Hiroki Tanaka

Akihide Onozawa

Gianfranco Pasut

Yuki Matsuno

Kazuhiro Hashimoto

Kenichiro Nakamoto

Takeshi Satou

Kazue Yoshida

Shinya Tamagawa

Nae Takata

Manami Konishi

Shingo Kimura

Tatsunari Takahashi

Aiko Kudo

Masakazu Katsu

Hyun Seok Song

Megumi Takayanagi

Tomohiro Shirosaki

Kenichi Iwakami

Kenichi Abe

Takanori Inaba

Atsushi Kawashima

Xiaohang Sun

Tatsuhiro Tanimura

Yuki Yamato

Ken-Ichiro Nakamoto

The invention provides a modified bio-related substance that shows further prolonged half-life in blood and further improved stability in the blood of living organisms. In particular, the invention provides a conjugate of a block polymer and a bio-related substance, which conjugate is represented by the following formula (I), wherein each symbol is as described herein.

Conjugate of bio-related substance and block polymer, and block polymer derivative for obtaining said conjugate

A branched degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A branched degradable polyethylene glycol derivative represented by the following formula (1), containing, in a molecule, an oligopeptide that is degraded in the cells: wherein kand kare each independently 1-12, jand jare each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and Land Lare each independently a single bond or a divalent spacer.

Asymmetrically branched degradable polyethylene glycol derivative

A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1): wherein n1 and n2 are each independently 45-950, Wand Ware each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, Xand Xare each independently a functional group capable of reacting with a bio-related substance, and L, L, L, L, Land Lare each independently a divalent spacer.

Degradable multi-arm polyethylene glycol derivative

A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.

Branched degradable polyethylene glycol binder

The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

Degradable polyethylene glycol conjugate

The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L, L, L, Land Lare each independently a single bond or a divalent spacer.

Degradable polyethylene glycol derivative

The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R, R, R, R, R, R, X, X, Y, Y, Z, and Zare as defined in the specification.

Cationic lipid exhibiting improved intracellular dynamics

A fluid-heating device for heating fluid with a heater includes: a heating portion that is molded so as to cover the surrounding of the heater; and a support body integrally cast into the heating portion, the heating portion being molded in a state in which the heater is supported by the support body in a die for molding the heating portion.

Fluid-heating device and manufacturing method thereof

A branched monodispersed polyethylene glycol represented by the formula (1): wherein Xis a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and Lrepresents a single bond, —NH—, -L-(CH)- or -L-(CH)-L-(CH)-, Lrepresents an ether bond, an amide bond, an urethane bond or a single bond, Lrepresents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.

Branched monodispersed polyethylene glycol, intermediate and methods for producing same

A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).

Method for producing multi-arm type polyethylene glycol derivative

An antenna device installed in a vehicle includes a stacked dipole antenna unit. The stacked dipole antenna unit has a plurality of dipole antennas that are arranged parallel to a plane perpendicular to a front-back direction of the vehicle.

Antenna device

A degradable polyethylene glycol derivative represented by formula (1). R, R, and Rrepresent each independently a hydrogen atom or a hydrocarbon group having from 1 to 6 carbon atoms, and at least one of R, R, Rand Ris the hydrocarbon group; Pis a straight-chain or branched polyethylene glycol chain having a number of ethylene glycol units of 3 or more; Pis a straight-chain polyethylene glycol chain having a number of ethylene glycol units of 3 or more; w is an integer of 1 to 8; u is an integer of 1 to 10; Xis a chemically reactive functional group; and Z, Zand Zare each independently a selected divalent spacer. 

Degradable polyethylene glycol derivative having disulfide linker

A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.

Production method of polyoxyethylene derivative having plurality of hydroxyl groups at terminal

A fluid-heating device for heating fluid includes: a heater having a heat generating part, the heat generating part being configured to generate heat upon application of current; an electric component configured to control the application of the current to the heater; a tank having an opening portion, the tank being configured to accommodate the heat generating part; a top-plate portion configured to close the opening portion of the tank, the top-plate portion being configured to form a fluid chamber through which the fluid flows; and a first communication port and a second communication port configured to allow the fluid to flow through the fluid chamber; wherein the electric component is provided on an outer side of the fluid chamber along the top-plate portion.

Fluid-heating device

A fluid-heating device for heating fluid includes a heater unit configured to have a heater and a heating portion, the heating portion being formed as to cover surrounding of the heater, wherein the heating portion has an inner heat exchange surface formed on an inner surface of a through hole penetrating through an inner side of the heater and an outer heat exchange surface formed on an outer-wall portion of an outer side of the heater, the inner heat exchange surface being configured to perform heat exchange with the fluid, and the outer heat exchange surface being configured to perform the heat exchange with the fluid.

Growing community of inventors

Kawasaki, Japan

Hiroki Yoshioka