Astrazeneca Ab

Dainippon Sumitomo Pharma Co., Ltd.

Astrazeneca Aktiebolag

Sumitomo Dainippon Pharma Co., Ltd.

Hiroki Wada

Roger Victor Bonnert

Stephen Thom

Yoshiaki Isobe

Stephen Brough

Ayumu Kurimoto

Thomas Mcinally

Thomas McInally

Kazuki Hashimoto

Ian Millichip

Tao Feng

Hitesh Jayantilal Sanganee

Anthony Ronald Cook

Phillip Abbott

Satoshi Onuma

Tom McInally

The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Zrepresents alkylene, Xrepresents oxygen atom, sulfur atom, SO, NR, CO, CONR, NRCO and the like, Y, Yand Yrepresent independently a single bond or an alkylene group, Xrepresents oxygen atom, sulfur atom, NR(Ris hydrogen atom or an alkyl group) or a single bond, Rrepresents a substituted or unsubstituted alkyl group, Rrepresents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

9-substituted 8-oxoadenine compound

The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy. 

Purine derivatives

The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Zrepresents alkylene, Xrepresents oxygen atom, sulfur atom, SO, NR, CO, CONR, NRCO and the like, Y, Yand Yrepresent independently a single bond or an alkylene group, Xrepresents oxygen atom, sulfur atom, NR(Ris hydrogen atom or an alkyl group) or a single bond, Rrepresents a substituted or unsubstituted alkyl group, Rrepresents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group]or its pharmaceutically acceptable salt.

The present invention provides compounds of formula (I) wherein R, R, R, R, X, Y, Z, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Imidazoquinolines with immuno-modulating properties

The invention concerns pyrazine derivatives of the Formula I or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.

Pyrazine derivatives

The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer. 

8-oxoadenine derivatives acting as modulators of TLR7

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Loughborough, United Kingdom

Hiroki Wada