Eisai Company, Limited

Hiroki Ishihara

Nobuhisa Watanabe

Hideyuki Adachi

Fumihiro Ozaki

Masayuki Matsukura

Shigeru Souda

Kazutoshi Miyake

Kazuki Miyazaki

Naoki Yoneda

Yasutaka Takase

Nobuyuki Mori

Toshiyuki Matsuoka

Kohtaro Kodama

Toshihiko Kaneko

Norio Minami

Yasuhiro Kabasawa

Sachiyuki Hamano

Keiji Ishibashi

Kohtarou Kodama

Takashi Musha

Osamu Hiroshima

Shuhei Miyazawa

Norio Karibe

Itaru Tsukada

Atsushi Kamada

Takao Saeki

Tadashi Nagakura

Yoshimitsu Naoe

Shinya Abe

Yoshinori Takahashi

Hironori Ikuta

Motosuke Yamanaka

Ichiro Yoshida

Junichi Kamata

Kohei Sawada

Tomonori Hoshiko

Mamoru Saito

Shinji Suda

Hiroshi Katoh

Takashi Yoshinaga

Kiyoaki Kobayashi

Mutsuko Tabata

Tatsuhiro Onogi

Hiroyuki Suzuki

Mitsumasa Shino

Miyuki Ohkubo

Mayu Shibazaki

Piperidine compound and pharmaceutical composition thereof

Phthalazine compounds and therapeutic agents for erectile dysfunction

Phthalazine derivatives and remedies for erectile dysfunction

The present invnetion provides a remedy for erectile dysfunction. The active ingredient thereof is a fused pyridazine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof:

Remedy for erection failure comprising fused pyridazine compound

Fused pyridazine compounds

Anthranilic acid derivatives

Nitrogen-containing fused-heterocycle compounds

Quinazoline compounds

The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1=A2--A3=A4-- is --CH=CH--CH=CH--, --N=CH--CH=CH--, --CH=N--CH=CH--, --CH=CH--N=CH--, --CH=CH--CH=N-- or --CH=N--CH=N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.

Biphenylmethane derivative and pharmacological use

A pyrrolidine compound having the following formula and a pharmacologically acceptable salt thereof is disclosed. It is useful in the pharmaceutical field. ##STR1## in which X is hydrogen, a halogen, or a lower alkyl, Y is --(CH2)n--, n being zero, 1 or 2, --S(O)p--, p being zero, 1 or 2, --O--, or --NH-- and R is phenyl, a substituent-having phenyl, naphtyl, a substituent-having naphthyl, a heteroaryl or a substituent-having heteroaryl.

Pyrrolidine compound and pharmaceutical use

The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)p--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is --CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.

The biphenylmethane derivative having the formula (I) is useful to prevent and treat hypertension and cardiac failure. ##STR1## in which R1 is hydrogen, an alkyl, a cycloalkyl, a halogenated alkyl, --S--R7, --SO2--R7, --C.tbd.C--R7 or --(CH2)--OR7, R7 being hydrogen, an alkyl, a cycloalkyl or a halogenated alkyl, p being zero or 1, --A1.dbd.A2--A3.dbd.A4-- is CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--, --CH.dbd.N--CH.dbd.CH--, --CH.dbd.CH--N.dbd.CH--, --CH.dbd.CH--CH.dbd.N-- or --CH.dbd.N--CH.dbd.N--, R2 and R3 are each hydrogen, a halogen, a lower alkyl, a lower alkoxy, a carbamoyl or cyano, R4 is hydrogen or a lower alkyl, R5 is 1H-tetrazol-5-yl, carboxyl (--COOH) or a carboxylic ester and R6 is hydrogen, a halogen, hydroxyl or a lower alkoxy, or a pharmacologically acceptable salt thereof.

Growing community of inventors

Ibaraki, Japan

Hiroki Ishihara