Ensuiko Sugar Refining Co., Ltd.

Other

Okayama University

Kaken Pharmaceutical Company, Ltd.

Jo Cosmetics Co., Ltd.

Hiroki Hamada

Yoshio Shimizu

Meisterbio Co., Ltd.

Tadakatsu Mandai

Hamada, Hiroki

Shimizu, Yoshio

Katsuhiko Mikuni

Koji Hara

Kozo Hara

Hiroshi Okumoto

Daisuke Uesugi

Nobuhiro Kuwahara

Hideki Takahashi

Masaharu Seno

Ryuta Yuasa

Kyoko Saito

Tomonari Kasai

Ichiro Fujiwara

Tsukasa Shigehiro

Yui Matsuhashi

Masaharu Murakami

An object of the present invention is to provide a cosmetic composition for use in sunscreen that exhibits a sufficient effect with a reduced content of a UV protection agent, and to provide a cosmetic composition for use in sunscreen that has excellent texture, usability, and antioxidant action, while having a UV protection effect. In order to achieve this object, an emulsified cosmetic composition for use in sunscreen comprising (A) trans-resveratrol polysaccharide and (B) a UV protection agent is provided.

Sunscreen cosmetic

In order to reduce the side effects of paclitaxel derivatives having excellent anti-cancer effects, an attempt was made to produce a liposome encapsulating paclitaxel derivatives such as paclitaxel monoglycosides and docetaxel monoglycosides. However, the introduction efficiency of paclitaxel derivatives, etc., into a liposome was poor, and this technique was not developed to a practical level. The present invention provides a method for producing a liposome encapsulating a paclitaxel monoglycoside and/or a docetaxel monoglycoside, and having an antibody specifically recognizing a cancer cell, the method comprising a step of bringing a liposome encapsulating a polyoxyethylene ester derivative, a lower alcohol, and a buffer or water into contact with a solution in which a paclitaxel monoglycoside and/or a docetaxel monoglycoside is dissolved in an alkylene glycol-containing buffer or water.

Method for producing liposome encapsulating paclitaxel monoglycoside and/or docetaxel monoglycoside

A sugar derivative wherein a hydroxy-carboxylic acid is combined to a position 1 of a sugar via ether linkage, and other hydroxyl groups are protected with a protective groups. A method of producing the sugar derivative, comprises allowing glycolic ester to react with a compound so as to combine said glycolic ester at the position 1 of the sugar skeleton, and then saponifying, said compound has on the position 1 any of hydroxyl group, halogen atom and sulfur atom with a substitutent group, and has other hydroxyl groups being protected with a protective groups.

Process for acylating the 1-position of saccharides

A taxoid derivative wherein sugar is combined with any one of paclitaxel, docetaxel and 10-deacetyl-bacatin III via a spacer. A method of producing the taxoid derivative comprises protecting hydroxyl groups at specific position of paclitaxel or docetaxel by protective compound followed by reacting with tetrabenzyl acetyloxyglucoside, and then carrying out debenzyl and detriethylsilyl reactions. A method of producing the taxoid derivative comprises reacting paclitaxel or docetaxel with tetrabenzyl acetyloxyglucoside, and then carrying out debenzyl reaction.

Taxoid derivative and method of producing thereof

There is provided an unbranched cyclodextrin or a branched cyclodextrin inclusion complex of taxol. The complex is produced by adding an unbranched cyclodextrin of a branched cyclodextrin to taxol at a molar ratio of 1-20 times with respect to taxol. A method is provided for the improvement of the solubility of taxol in water by adding an unbranched cyclodextrin or a branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to taxol. The solubility of taxol in water is improved by the present invention. A cyclodextrin inclusion complex of taxol according to the present invention serves to make taxol more easily absorbed when administered to a cancer patient, which is beneficial to cancer patients and the physiological effects of taxol may therefore be more effectively induced.

Cyclodextrin inclusion complex of taxol, and method for its production

Growing community of inventors

Okayama, Japan

Hiroki Hamada