Nippon Zoki Pharmaceutical Co., Ltd.

Osaka University

Hiroki Fujisawa

Mitsuru Naiki

Hideki Yoshikawa

Kusuki Nishioka

Hiroyuki Tanaka

Tsuyoshi Murase

Tomohiro Kato

Takumi Numazawa

Nigishi Hotta

A Schwann cell differentiation promoting agent, a peripheral nerve regeneration promoting agent, or the like contain an extract from inflamed tissues inoculated with vaccinia virus. The extract from inflamed tissues inoculated with vaccinia virus promotes differentiation of Schwann cells and regeneration of a peripheral nerve. Therefore, a preparation containing the extract from inflamed tissues inoculated with vaccinia virus is useful as a Schwann cell differentiation promoting agent, a peripheral nerve regeneration promoting agent, or the like.

Schwann cell differentiation promoting agent and a peripheral nerve regeneration promoting agent

A method for prophylactically or therapeutically treating an inflammatory disease and/or degenerative intervertebral disk disease in a subject is disclosed. The method includes administering to the subject an effective amount of a coumarin derivative represented by formula (I), or a pharmaceutically acceptable salt or hydrate thereof: Each of R1 and R2 is independently (a) phenyl optionally substituted with alkoxy, alkyl, cyano, nitro, hydroxy, trifluoromethyl, amino, carboxy, alkoxycarbonyl, phenyl, or one or two halogen(s), (b) pyridyl, (c) alkyl, or (d) thienyl.

Therapeutic/ preventive agent containing coumarin derivative as active ingredient

A method for studying, determining or evaluating a pharmacological action of a test substance, the method including subjecting the brain tissue of an SART stressed animal administered with the test substance to an expression proteome analysis, where expression changes of NSF (N-ethylmaleimide sensitive fusion protein), which is or is not modified after translation, in the SART stressed animal administered with the test substance as compared with an SART stressed animal to which a test substance is not administered is used as an index.

Method for studying, determining or evaluating pharmacological actions of a test substance on an sart stressed animal

The production of 3-deoxyglucosone, which is an intermediate in the Maillard reaction and induces a crosslinking glycation of proteins participating in various diseases, is inhibited with an inhibitor containing at least one parabanic acid derivative as an effective ingredient. The at least one parabanic acid derivative is represented by the following formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein, R is hydrogen or lower alkyl; X is hydrogen, alkyl, cycloalkyl, lower alkylcycloalkyl, phenyl or phenylalkyl which is optionally substituted with lower alkyl, lower alkoxy, nitro and/or halogen; and n is an integer of from 1 to 4. Inhibiting the production of 3-DG, which is a highly active intermediate which participates in the formation of crosslinked protein in the Maillard reaction is useful for the treatment and the prevention of various diseases induced by deposition into tissues or sclerosis or denaturation of crosslinked protein, or diseases induced by aging and diabetic complications.

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Osaka, Japan

Hiroki Fujisawa