Nippon Shinyaku Company, Ltd.

Hirokazu Ushimaru

Yutaka Takahashi

Masanobu Kawamata

Sho Inoue

Koichi Nakamichi

Akira Sano

A process for producing amorphous preparations of steryl glucoside monopalmitates, wherein steryl glucoside monopalmitates are heated at a temperature above 110.degree. C up to about 145.degree. C or the compounds are dissolved in an organic solvent in which they are soluble with a solvent which is then distilled off, and the compounds then pulverized and mixed with physiologically harmless organic or inorganic fine particles in a proportion of 0.5 times (by weight) of the compounds or more, thereby homogeneously dispersing the amorphous compounds in the fine particles or uniformtly adsorbing the compounds on the fine particles, and the resulting preparations which have hemostatic properties and are readily absorbable upon ingestion. The starting steryl glucoside monopalmitates are obtained in crystalline form as from soy beans or other vegetable sources.

Process for producing easily absorbable amorphous steryl glucoside

Sterol glycosides are rendered easily absorbable through the digestive tract by dissolving or dispersing the steroid glycoside with heating into a water solution of a polymer or polymers and then removing the solvent.

Process for preparing easily absorbable sterol glycoside

A method of preparing aqueous solutions of sterol glycosides and their ester derivatives characterized by solubilizing sterol glycosides and their ester derivatives by (1) dissolving said sterol glycoside or ester in a lower aliphatic alcohol and subsequently adding a hydrophilic non-ionic surface active agent, or (2) mixing or dissolving said sterol glycoside or ester with or in a lipophilic surface active agent or its solution in an organic solvent miscible with water and subsequently adding a hydrophilic surface active agent.

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Kyoto, Japan

Hirokazu Ushimaru