Harvard College

Hirokazu Tsukamoto

Daniel E Kahne

Suzanne Walker Kahne

Emma Doud

Yi Zhang

Christian Gampe

Christian M Gampe

Xiaonan Lin

Bohdan Ostash

Masaatsu Adachi

Shinichiro Fuse

The present invention provides moenomycin-based probe compounds of Formula (I) for use in screening inhibitors of bacterial glycosyltransferases. The present invention also provides bacterial glycosyltransferase screening assays using compounds of Formula (I).

Methods and compounds for identifying glycosyltransferase inhibitors

The present invention provides methods of synthesizing moenomycin analogs of Formula (I). The present invention also provides compositions comprising a compound of Formula (I) and kits for synthesizing compounds of Formula (I). 

Chemoenzymatic methods for synthesizing moenomycin analogs

The present invention provides compounds of Formula (I); or a pharmaceutically acceptable form thereof; wherein R,R,R,R,R,R,R, and Rare as defined herein, and G is a group of Formula (a), (b), or (c): Formula (II), wherein X; X, X, X, X, X, X, Y, R, R, R, a, d, e, x, n, and m are as defined herein. The present invention further provides pharmaceutical compositions comprising a compound of Formula (I), kits comprising such compositions, methods of use and treatment, and preparative methods. 

Moenomycin analogs, methods of synthesis, and uses thereof

The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

Growing community of inventors

Sendai, Japan

Hirokazu Tsukamoto