Sankio Chemical Co., Ltd.

Hirokazu Suda

Taichi Shintou

Ken Umihara

Fumiaki Ikeuchi

A process for producing a 2-pyridylpyridine derivative usable as an intermediate for medicines or agricultural chemicals is provided, which does not require expensive metal catalysts, which does not cause environmental problems, and which can be conducted on an industiral scale. The process comprises the step (A) of producing an amidrazone compound from a cyano group-containing heterocyclic compound in water, the step (B) of producing a 1,2,4-triazine compound from the amidrazone compound in water, and the step (C) of producing a 2-pyridylpyridine derivative from the 1,2,4-triazine compound.

Process for the production of 2-pyridylpyridine derivatives

A process for producing a 2-pyridylpyridine derivative usable as an intermediate for medicines or agricultural chemicals is provided, which does not require expensive special catalysts and special equipment, which does not cause environmental problems, and which can be conducted on an industiral scale. The process comprises reacting an acetyl-substituted pyridine derivative with a 3-amino acrolein, then reacting the reaction product with ammonia or an ammonium salt.

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Kanagawa, Japan

Hirokazu Suda