Toray Industries, Inc.

Hirokazu Sakaguchi

Kenichi Harimoto

Kazuhiro Tanahashi

Satoshi Yamada

Yoshiyuki Ueno

Hiroshi Takahashi

Hiroyuki Sugaya

Koji Kadowaki

Akihiro Hayashi

Yoshinori Kakizawa

Kazuyuki Kidoba

Kaori Akaike

Kota Hatta

Kanta Tanabe

The present invention aims to provide a porous separation membrane that does not suffer a significant decrease in the protein permeability even after long term use. The porous separation membrane has an asymmetric structure with a dense layer forming one surface layer and with a coarse layer forming the other surface layer, supports a biocompatible polymer, and meet the requirements (1) and (2) given below in surface analysis of a cross section containing the dense layer and the coarse layer performed by TOF-SIMS:

Porous separation membrane

The present invention provides a medical molded article including a bioabsorbable polyester and having excellent followability to a living body, and the present invention is a medical molded article including a bioabsorbable polyester, the medical molded article having an amount-of-work-holding rate of 55% or more, the amount-of-work-holding rate defined as a rate of an amount of work generated finally by an operation that is repeated 10 times to an amount of work generated first by the operation, the operation in which a tensile stress is applied to the medical molded article in a direction of a maximum length of the medical molded article to generate a tensile strain of 100% with respect to an initial length.

Medical molded article, medical device, and nerve guidance conduit

A polymer composition contains polylactic acid and a dilactide/ε-caprolactone copolymer, in which a content of the polylactic acid relative to a total of 100 mass % of the polylactic acid and the dilactide/ε-caprolactone copolymer is 20 to 40 mass %, and in which the dilactide/ε-caprolactone copolymer satisfies (1) an R value represented by a following formula is 0.45 or more and 0.99 or less: where [A] is a molar fraction (%) of a dilactide residue in the dilactide/ε-caprolactone copolymer, [B] is a molar fraction (%) of an ε-caprolactone residue in the dilactide/ε-caprolactone copolymer, and [AB] is a molar fraction (%) of a structure in which a dilactide residue and an ε-caprolactone residue are adjacent to each other (A-B and B-A) in the dilactide/ε-caprolactone copolymer, and (2) at least one of the dilactide residue and the ε-caprolactone residue has a degree of crystallization of less than 14%.

Polymer composition, molded body, and nerve regeneration inducing tube

A nerve regeneration-inducing tube includes a cylindrical body, and a plurality of fibers that are housed in the body and extend in a longitudinal direction of the body. At least a part of the fibers is a modified cross-section fiber that has an axis extending in a longitudinal direction of the fibers, and at least three protrusions that continue in the longitudinal direction of the fibers, protrude from the axis, and have a height of 0.5 μm or more from the axis.

Nerve regeneration-inducing tube

A cell adhesive substrate comprising a substratum, on a surface of which a peptide group is immobilized, wherein the peptide group comprises a peptide containing 40% or more and 75% or less of one or two or more of basic amino acid residues selected from the group consisting of lysine, arginine and histidine and 25% or more of one or two or more of hydrophobic amino acid residues selected from the group consisting of leucine, isoleucine, glycine, alanine, valine, phenylalanine, proline, tryptophan and methionine. There is provided a cell adhesive substrate that is unlikely to cause an immune reaction and can maintain a cell adhesion effect for a long time.

Cell adhesive material

The present invention provides a hollow fiber membrane module which makes it possible to concentrate incubated platelets by efficiently removing water from an incubated platelet suspension liquid containing incubated platelets while suppressing deterioration of the function of the incubated platelets. The present invention provides an incubated platelet concentration module in which a plurality of hollow fiber membranes each having pores with an average pore diameter of 2 &#x3bc;m or less on a surface of the hollow fiber membrane are packed in a casing having at least one inlet for supplying an incubated platelet suspension liquid before concentration into the hollow fiber membranes, wherein a value (X/Y1) obtained by dividing a total cross-sectional area (X) of the plurality of hollow fiber membranes by a total cross-sectional area (Y1) of the least one inlet is 4.0 or less.

Incubated platelet concentration module and method for producing platelet preparation using same

A polyester copolymer has two types of ester bond-forming monomer residues as main structural units when the two types of ester bond-forming monomers are defined as 'monomer A' and 'monomer B', respectively, the polyester copolymer satisfies (1) and (2): (1) an R value represented by equation:value=[]/(2[][])&#xd7;100[A]: mole fraction of monomer A residues in the polyester copolymer [% by mol], [B]: mole fraction of monomer B residues in the polyester copolymer [% by mol], and [AB]: mole fraction of a structure in which the monomer A residues and the monomer B residues are adjacent to each other (A-B and B-A) in the polyester copolymer [% by mol], is 0.45 or more and 0.99 or less; and (2) a crystallization rate of at least one of the monomer A residues and the monomer B residues is less than 14%.

Polyester copolymer and method of producing same

The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 &#x3bc;g/ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.

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Otsu, Japan

Hirokazu Sakaguchi