Toyama Chemical Co., Ltd.

Handi-Pac, Inc.

Hirokazu Narita

Satoshi Ono

Mutsuko Maekawa

Yozo Todo

Tetsuo Yamafuji

Isamu Saikawa

Yasuo Watanabe

Hisaaki Chaki

Yoshinori Konishi

Kazunari Hirata

Hiroyuki Imaizumi

Shuntaro Takano

Takihiro Inaba

Masaru Tai

Hiroshi Sadaki

Hideo Taki

Tatsuo Hirakawa

Isao Kitayama

Mikako Miyajima

Hideyoshi Nagaki

Hiroshi Sakai

Minako Yotsuji

Kazuya Hayashi

Jun Nitta

Junichi Mitsuyama

Katsuyuki Nagumo

Keiko Takakura

Tetsuya Kajita

Akira Yotsuji

Kenichi Takashima

Katsumi Shimizu

Masahiro Takahata

Shinzaburo Minami

Yoshikazu Fukuoka

Hiroyasu Takagi

Hajime Aoyama

Fumihiko Iino

Shunjiro Misumi

Nobuyuki Matsubara

Yoriko Nagai

Osamu Oohashi

Masahiro Tadahata

A 1,2-ethanediol derivative represented by the general formula [I] or its salt: ##STR1## has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervous system such as senile dementia of Alzheimer type, Huntington's chorea, various neuropathies, Riley-Day syndrome, traumatic nerve injury, amyotrophic lateral sclerosis (ALS) and the like.

Agent for potentiating nerve growth factor activity containing

Quinolonecarboxylic acid derivatives or salts thereof

Quinolone- or naphthylidone-carboxylic acid derivates or their salts

A 1,2-ethanediol derivative represented by the general formula �I! or its salt: ##STR1## has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervous system such as senile dementia of Alzheimer type, Huntington's chorea, various neuropathies, Riley-Day syndrome, traumatic nerve injury, amyotrophic lateral sclerosis (ALS) and the like.

This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebrovascular dementia, senile dementia, Alzheimer's dementia, sequelae of ischemic encephalopathy and cerebral apoplexy.

1,2-ethanediol derivative and salt thereof, process for producing the

1,2-ethanediol derivative and salt thereof and cerebral

1,2-ethanediol derivative and salt thereof process for producing the

The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.5 is a substituted or unsubstituted alkoxy group or a group of the formula ##STR4## (R.sup.7 and R.sup.8 are as defined above), and R.sup.6 is a hydrogen atom or a substituted or unsubstituted alkyl group.

Triazole derivatives and salts thereof, and antifungal agent containing

Triazole derivatives and salts thereof and antifungal agent containing

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Toyama, Japan

Hirokazu Narita