Sumitomo Seika Chemicals Co., Ltd.

Sumitomo Chemical Company, Limited

Hirokazu Kagano

Hiroshi Goda

Shigeki Sakaue

Syuzo Satake

Noriyuki Hayashizaka

Mikio Yamamoto

Katsuhiko Yoshida

Ichiro Fuseya

Muneaki Tanaka

Masahito Nakano

Takeshi Takeuchi

Michio Suzuki

Hiroyuki Hata

Seiji Bando

Takehiro Hiyama

Hitoshi Karino

Masaki Teramoto

Hidehiko Myoken

Kenji Kogami

Masato Yoshikawa

Toshiyuki Ohe

Kenichi Wakimura

Miki Toudou

The present invention provides a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by Formula (1); 

(E)-N-monoalkyl-3-oxo-3-(2-thienyl) propenamine and process for producing the same and process for producing (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl) propenamine

The present invention provides a process for producing a methylene disulfonate compound in a simple manner at low cost. The present invention provides a process for producing a methylene disulfonate compound represented by General Formula (2) comprising:  

Process for production of methylene disulfonate compound

The present invention provides a process for producing an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine represented by General Formula (2): wherein R is Calkyl, comprising the step of reducing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by General Formula (1): wherein R is as defined above. According to the present invention, an N-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine which is for use as an intermediate for various pharmaceuticals can be produced in an industrially inexpensive and easy manner.

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The present invention provides a process for producing a 2-acylthiophene compound which has a low content of the 3-isomer generated as a by-product, the process comprising reacting a thiophene compound represented by formula (1):    

Process for producing 2-acylthiophene compound

It is an object of the present invention to provide a process for producing highly pure 4-bromothioanisole, which is useful in the manufacture of medicinal chemicals, agrochemicals or functional materials, in a simple and industrially advantageous manner. The present invention is related to a process for producing 4-bromothioanisole

Process for producing 4-bromothioanisole

Processes for producing isothiazole derivatives

A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime with a halogenating agent; and a method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-halobenzonitrile with an alkanethiol in a heterogeneous solvent system in the presence of a base to give a 2-(alkylthio)benzonitrile and carrying out a reaction of the 2-(alkylthio)benzonitrile with an halogenating agent in the presence of water.

Method for producing 1,2-benzisothiazol-3-ones

A method for producing an alkylthiobenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of an alkylthiobenzamide with a halogen in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying cut a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent and a subsequent reaction with a halogen; and a method for producing a 1,2-benzisothiazol-3-one by carrying out a reaction of a 2-(alkylthio)benzamide with a halogenating agent.

Method for producing alkylsulfinylbenzamides and 1-2

A method for producing an alkylthiobenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of an alkylthiobenzamide with a halogen in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent and a subsequent reaction with a halogen; and a method for producing a 1,2-benzisothiazol-3-one by carrying out a reaction of a 2-(alkylthio)benzamide with a halogenating agent.

Method for producing alkylsulfinylbenzamides and

A 2-alkylthiobenzaldehyde of general formula (I) is reacted with a halo compound of general formula (II) to produce a 2-substituted benzo[b]thiophene of general formula (III): ##STR1## wherein R.sup.1 means an alkyl group of 1 to 4 carbon atoms,

Processes for producing 2-substituted benzo[B]thiophene

The present invention is directed to a method for producing dichlorophenylthioglycolic acid which comprises reacting monobromodichlorobenzene or trichlorobenzene with a thioglycolate in a ratio of 0.5 to 2.5 mols of the latter to 1 mol of the former in a polar solvent, and to a method for producing dichlorophenylthioglycolic acid comprising further reacting the reaction mixture obtained as above with a monohalogenoacetate. The method of the present invention is very useful industrially, advantageously producing dichlorophenylthioglycolic acid in high yield.

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Hyogo, Japan

Hirokazu Kagano