Daicel Chemical Industries, Ltd.

Nissan Chemical Industries Limited

Hirokazu Ikeda

Koichi Murazumi

Atsushi Onishi

Hiroo Matsumoto

Yoshio Ohara

Fumihiko Shoji

Masakazu Negawa

Tatsushi Murakami

Hiroyasu Kanda

The present invention provides a production method with which a porous carrier can be allowed to evenly carry a polysaccharide derivative. That is, the present invention provides a method of producing an enantiomeric isomer-separating filler, including bringing a porous carrier and a solution of a polysaccharide derivative into contact with each other through a stirring operation in a stirring device, to allow the porous carrier to carry an optically active polymer compound, in which: a two-axis vertical stirring device is used as the stirring device; and the porous carrier is allowed to carry the polysaccharide derivative in a carrying amount of 23 mass % or more.

Process for producing packing for resolving optical isomers

The objectives of this invention are to provide a filler for separating optical isomers, capable of efficiently carrying out optical resolution of optical isomer mixtures, a process for producing the filler, and a method for using the filler. The present invention provides a process for producing a filler for separating optical isomers which process comprises stirring a carrier and a solution including an optically active polymer compound with a double spindle vertical mixer. The present invention further provides a filler produced by the process and a method for using the filler in liquid chromatographic separation methods and simulated moving bed chromatographic separation methods.

Optical isomer separating filler, production method therefor and application method therefor

A simulated moving bed separation system is provided, in which a fluid circulation flow path can be washed for a short time. This system is provided with a circulation flow path having two or more packed beds connected in series and endlessly to each other, with desorbing-charging inlet, extract draw-out port, feedstock introducing port and raffinate draw-out port arranged in this order in the direction of flow of a circulation liquid, which are allowed to intermittently shift in the direction while being kept in this order, and with packed bed-washing pipes, valves and pumps. A desorbing liquid is introduced through the desorbing liquid introducing port into the circulation flow path. An extract rich in a strongly adsorptive constituent to be separated is drawn out through the extract draw-out port. A feedstock containing strongly and weakly adsorptive constituents is introduced through the feedstock introducing port into the circulation flow path, and a raffinate rich in a weakly adsorptive constituent is drawn out through the raffinate draw-out port.

Simulated moving bed separation system

The method of separation of optical isomers in accordance with the present invention is directed to providing a method of separation of optical isomers which enables efficient optical resolution of optical isomer mixture not using expensive silica gel but using a filler which is inexpensive per se and has excellent optical resolution ability, and characterized in that particles of polysaccharide derivatives, preferably ester derivatives and carbamate derivatives of polysaccharide are used as an optical resolution filler.

Method for separation of optical isomers

A simulated moving bed chromatographic separation system for separating from a feedstock the constituents thereof, comprising packed beds filled with separating fillers, is provided, by which the separation performance of the packed beds can be evaluated without removing the packed beds from the circular fluid passage. This system is further provided with the circular fluid passage having at least four packed beds connected in series and endlessly to each other, a desorbing liquid introducing port, an extract draw-out port for drawing out the extract containing a larger amount of a constituent strongly adsorbed on the fillers, of constituents contained in a feedstock from the circular fluid passage, a feedstock introducing port for introducing the feedstock into the fluid circulating passage, and a raffinate draw-out port for drawing out the raffinate containing a larger amount of a constituent weakly adsorbed on the fillers, of the constituents. The desorbing liquid introducing port, extract draw-out port, feedstock introducing port and raffinate draw-out port are arranged so that these ports may be intermittently shifted on the fluid circulating passage without changing this order. This system is also provided with packed bed performance evaluating means.

Simulated moving bed chromatographic separation system

Process for preparing optically active mevalonolactone compounds

In the simulated moving bed chromatographic separation process, preferably using a simulated moving bed chromatographic separation apparatus with rotary valves and/or check valves, a supercritical fluid is used as an eluent and thereby efficiency in separation and operation is remarkably improved and the concentration step after the chromatographic separation is not required.

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Arai, Japan

Hirokazu Ikeda