Tohoku University

Shionogi Company Limited

Nagoya University

Hirokazu Arimoto

Daiki Takahashi

Kaori Itto

Osamu Yoshida

Tsutomu Iwaki

Kenji Morimoto

Jun Lu

Yoshinori Yamano

Yutaka Yoshida

Issei Kato

Tatsuro Yasukata

Taiichi Ohra

Nobuo Cho

Jun Moriyama

Shigekazu Sasaki

Kayo Yasoshima

Kenichiro Shimokawa

Naoki Ishii

Hiroshi Nara

Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.

Heterocyclic compound

Provided is a degrader for injured mitochondria based on an autophagy mechanism, the degrader including a compound or a salt thereof, the compound containing a ligand capable of binding to or accumulating in mitochondria and a substituent represented by the following general formula (1): where R, R, and Rare identical to or different from each other, and each represent a hydrogen atom or the like.

Degradation agent using autophagic mechanism of damaged mitochondria

Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)&#x2014;R[wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and Rrepresents, e.g., the formula &#x2014;X&#x2014;Ar&#x2014;X&#x2014;Y&#x2014;X&#x2014;Ar(wherein X, X, and Xeach represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of &#x2014;N&#x2550;, &#x2550;N&#x2014;, &#x2014;NR&#x2014;, &#x2014;O&#x2014;, etc.; Y represents &#x2014;NRCO&#x2014; or &#x2014;CONR&#x2014; (wherein Rrepresents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.

Glycopeptide antibiotic monomer derivatives

Growing community of inventors

Sendai, Japan

Hirokazu Arimoto