Banyu Pharmaceutical Co. Ltd

Hirokatsu Ito

Osamu Okamoto

Hisashi Ohta

Satoshi Ozaki

Kensuke Kobayashi

Tomohiro Tsujita

Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I) [in the formula, A, Aand Aindependently represent a carbon atom or a nitrogen atom, and one or two of A, Aand Arepresent a carbon atom; Rrepresents a lower alkyl group or the like; Rrepresents a phenyl group which may be substituted with a halogen atom or the like; Rrepresents a hydrogen atom, a lower alkyl group or the like; and Rrepresents a lower alkyl group or the like.]

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Tsukuba, Japan

Hirokatsu Ito