Takeda Chemical Industries, Inc.

Hiroichi Yamamoto

Satoshi Horii

Yukihiko Kameda

Takashi Iwasa

Novel antibiotics, termed validamycins C, D, E and F, and acid salts thereof, are prepared by cultivating a validamycin-producing strain of microorganism of the genus Streptomyces, and optionally converting the free base to its acid salt. These antibiotics, as well as validoxylamines A and B, are useful for controlling plant diseases, and can be applied to the plants in the form of the cultured broth, filtrate or concentrate thereof, or purified preparation thereof.

Antibiotic compositions containing validamycin compounds

Novel antibiotics, termed validamycins C, D, E and F, and acid salts thereof, are prepared by cultivating a validamycin-producing strain of microorganism of the genus Streptomyces, and optionally converting the free base to its acid salt.

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Kobe, Japan

Hiroichi Yamamoto